Pathogenesis of bleb formation in idiopathic pneumothorax

目的：可引起自发性气胸发展的气泡。我们进行了一项研究，以确定在气泡形成过程中存在一种特定的病原体。方法：从自发性气胸手术切除的肺中提取RNA和DNA，采用灵敏的穷尽搜索法对病原菌进行基因搜索。结果：水泡部位检出TTV、HHV-6、HHV-7、EBV、细小病毒B19等病毒。但除了细小病毒B19外，这些病毒可以从正常肺组织中检测到。泡形成与这些病原体的相关性目前尚不清楚。结论：鉴定出的特异性病原体均不能使组织起泡，可能是气胸的发病机制。

Purpose: The Bleb, which can cause spontaneous pneumothorax development. We conducted a study in order to identify the presence of a specific pathogen in the formation of the Bleb. Method: From the lungs excised during spontaneous pneumothorax surgery, by extracting RNA and DNA, was subjected to gene search using a sensitive exhaustive search method pathogens.Result: Such as TTV, HHV-6, HHV-7, EBV, parvovirus B19 were detected from Bleb part. But these viruses are detected from the normal lung tissue, except parvovirus B19. Relevance of bleb formation and these pathogens unknown at this time. Conclusion: Identification of specific pathogens were unable to Bleb tissue that could be the pathogenesis of pneumothorax.