Pharmacological analysis of antispasmogenic with wire myograph

为避免游离组织移植中的血管痉挛，利多卡因已被广泛应用。 另一方面，利多卡因的适当浓度是未知的。 本文介绍了用于利多卡因或其他抗痉挛物质的药理学和生理学分析的钢丝肌电描记系统。 我们检查了盐酸罂粟碱、酚妥拉明、盐酸奥普利农、硝酸甘油和前列腺素E1。 结果表明，除前列腺素E1外，其他物质均表现出浓度依赖性的抗痉挛活性。 另一方面，前列腺素E1显示浓度依赖性痉挛活性，这可能是由炎症活动引起的。 这些物质可作为显微外科手术中的抗痉挛药物。

To avoid the vascular spasm during microvascular surgery for free tissue transfer, lidocaine has been widely used. On the other hand, the proper concentration of lidocaine is unknown. We introduced wire-myograph system for pharmacological and physiological analysis of lidocaine or other substances for its anti-spasmogenic activity. We examined papaverine hydrochloride, phentolamine messmate, olprinone hydrochloride, nitroglycerine, and prostaglandin E1. On the result, those substances, except prostaglandin E1, showed concentration-dependent anti-spasmogenic activity. On the other hand, prostaglandin E1 showed concentration-dependent spasmogenic activity which may be caused by inflammatory activity. In conclusion, those substances may be used for anti-spasmogenic agent during microsurgical operation.