Attempt to control ARE-mRNA expressed in oral cancer cells

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In this study, we examined the features of pp32 in order to develop the cancer therapy utilizing the control of pp32 expression in oral cancer cells. Over-expression of pp32 down-regulated the anchorage-independent growth activity of oral cancer cells. On the other hand, the knock-down of pp32 inhibited the export and stabilization of ARE-mRNA and conferred the anchorage-independent growth ability for oral cancer cells.These results indicate that the pp32 expression changes the features of oral cancer cells and that the possibility of the cancer therapy using pp32 over-expression.