Coupling strategies for planar solid phase extraction with gas chromatography using the example of mineral oil saturated and aromatic hydrocarbons (MOSH and MOAH)

平面固相萃取（pSPE）和气相色谱（GC）耦合的基本技术有待发展。pSPE-GC耦合的基础是使用具有挑战性的痕量分析包装材料和干燥低脂食品中的饱和和芳香矿物油碳氢化合物（MOSH和MOAH）进行研究。需要开发和优化两种不同的耦合技术。一方面，将目标分析物从薄层板上洗脱后，通过进液方式与GC耦合；另一方面，研究热解吸直接、无歧视、无损耗耦合。对于这两种策略，多功能且经济高效的pSPE用于MOSH和MOAH馏分的预分离，取代了目前使用的LC或SPE预分离。通过pSPE与GC的耦合，pSPE的可访问分析物范围（实际上仅限于lc适用的分析物）大大扩大了。利用开发的pSPE- gc耦合技术，有效的pSPE概念不仅适用于MOSH/MOAH物质类别，而且还允许对广泛的gc适用物质进行高效，可靠和高选择性的分析，精确定量到痕量水平。进一步的目标是开发pSPE，耦合光谱检测（UV/FLD），作为快速筛选工具，可靠地定量食品包装材料，化妆品和干燥，低脂食品中的MOSH和MOAH，直接在薄层板上平行进行许多样品。最后，将开发的pSPE、UV/FLD和GC-FID技术相结合，提供高效、模块化设计的整体分析策略，可用于整个MOSH/MOAH分析领域，并可轻松适应进一步的气相色谱适用的物质类别。通过与当前在线LC-GC-FID方法的结果比较，验证了所建立的pSPE-UV/FLD-GC-FID策略的适用性和准确性。

The fundamental techniques for the coupling of planar solid phase extraction (pSPE) with gas chromatography (GC) should be developed. The basics for the pSPE-GC coupling are studied using the challenging trace analysis of saturated and aromatic mineral oil hydrocarbons (MOSH and MOAH) in packaging materials and dry, low-fat foodstuffs. Two different coupling techniques are to be developed and optimized. On the one hand, pSPE is coupled to GC by liquid injection after the elution of the target analytes from the thin-layer plate, and on the other hand, the direct, non-discriminatory and loss-free coupling by thermal desorption is to be investigated. For both strategies, the versatile and cost-effective pSPE is used for the pre-separation of the MOSH and MOAH fractions and replaces the currently used LC or SPE pre-separation. By the coupling of pSPE to GC, the accessible analyte range for pSPE which actually is limited to LC-amenable analytes, is considerably expanded. Using the developed pSPE-GC coupling techniques, the effective pSPE concept will not only be applicable for the MOSH/MOAH substance classes, but will also allow the efficient, reliable and highly selective analysis for a wide range of GC-amenable substances, with the exact quantitation down to trace levels. A further objective is to develop the pSPE, coupled to spectroscopic detection (UV/FLD), as a fast screening tool for the reliable quantitation of MOSH and MOAH in food packaging materials, cosmetics, and dry, low-fat foods for many samples in parallel directly on the thin-layer plate. Finally, the developed techniques for pSPE, UV/FLD and GC-FID are combined to offer an efficient, modular designed overall analysis strategy, which can be used for the entire field of MOSH/MOAH analysis and can easily be adapted to further GC-amenable substance classes. The developed pSPE-UV/FLD-GC-FID strategy is tested for its suitability and trueness by comparing the results with data obtained by the currently used on-line LC-GC-FID method.