Mechanics of Nucleosome Array Assembly (B12*)

核小体阵列内的核小体位置由核小体-核小体相互作用、DNA序列依赖性核小体稳定性和活性染色质重塑的相互作用决定。在这里，我们研究了所观察到的核小体气体统计如何从潜在的机制中稳健地出现，以及这些机制如何允许核小体阵列在被破坏后快速重建，例如在DNA复制过程中。我们将采用统计和软物质物理学方法的组合。

Nucleosome positions within nucleosome arrays are determined by an interplay of nucleosome-nucleosome interactions, DNA sequence-dependent nucleosome stability, and active chromatin remodeling. Here, we study how the observed nucleosome gas statistics can robustly emerge from the underlying mechanisms, and how these mechanisms permit the rapid re-establishment of nucleosome arrays after they have been disrupted, e.g. during DNA replication. We will employ combinations of methods from statistical and soft-matter physics.