Immunmodulation of cytomegalovirus latency and reactivation by regulatory T cells and dendritic cells (14)

在骨髓移植(BMT)后，巨细胞病毒(CMV)感染危及移植受者的生存，因为免疫反应不能有效地防止病毒的发病和清除。我们计划研究调节性T细胞(Tregs)，尤其是CD8Tregs，在骨髓移植后抑制保护性CD8T细胞对小鼠CMV的反应中所起的作用。此外，我们还将研究树突状细胞(DC)在树突状细胞的产生和功能中的作用。在骨髓移植和巨细胞病毒感染的背景下，更好地理解Tregs的作用及其与DC的相互作用，对于发展基于细胞的治疗方法是至关重要的。

After bone marrow transplantation (BMT), cytomegalovirus (CMV) infections imperil the survival of transplant recipients as the immune response is not efficient in preventing morbidity and clearance of the virus. We plan to investigate the role of regulatory T cells (Tregs), of CD8 Tregs in particular, in suppression of protective CD8 T cells in response to murine CMV after BMT. Furthermore, we will study how dendritic cells (DCs) contribute to the generation and function of Tregs. An improved understanding of the role of Tregs and their interaction with DCs in the context of BMT and CMV infection is of fundamental importance for the development of cell-based therapeutic approaches.