Development of the functional mutagenesis system on Plasmodium prarasite

基因突变是传染病研究的有力工具。因此，在兽医学领域中，寄生虫病突变体筛选系统的开发是迫切需要的。 本研究以小鼠疟原虫为模型，尝试建立基于转座子的随机突变体筛选系统。因此，我们成功地建立了功能获得性突变体寄生虫文库系统。此外，利用该系统，我们还成功地鉴定了与媒介传播密切相关的基因组位点。

Genetic mutant is a powerful tool for the infectious disease research. Thus, the development of mutant screening system in the parasitic disease in veterinary field is desired. In this study, we tried to develop the transposon based random mutant screening system using murine malaria parasite as a model pathogen. As a result, we successfully established the gain-of function mutant parasite library system. Furthermore, with this system, we successfully could identify the genomic locus that highly concerns to vector transmission.