Molecular dissection of the vector-parasite relationship using Aedes-Filaria transmission system

利用伊蚊-丝虫传播系统对媒介-寄生虫关系进行分子解剖

• 批准号: 19380165
• 负责人: FUKUMOTO Shinya
• 金额: $ 12.9万
• 依托单位: Obihiro University of Agriculture and Veterinary Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19380165/
• 关键词: イヌ; フィラリア; ヤブカ; 寄生虫; 宿主適応

The host -parasite relationship in vector mosquito, Aedes, and Filaria parasite was analyzed. Our data indicated that the mosquito innate immune systems were not significantly affect filarial infection to mosquito vector. This result suggested the presence of completely different anti-pathogen system against filarial parasite compare to small pathogens such as protozoa, bacteria or virus. The molting related genes of filarial parasite were considered as have a key role for host transition. Especially, cut1 gene transcripts were specifically detected in host transition stage. This result indicated that cut1 could be a useful drug target for establishing novel filarial parasite infection controlling strategy.

分析了媒介蚊、伊蚊和丝虫病媒的宿主-寄生虫关系。结果表明，蚊虫的先天免疫系统对丝虫病媒的感染无显著影响。这表明丝虫病存在与原生动物、细菌或病毒等小病原体完全不同的抗病原体系统。丝虫病的蜕皮相关基因被认为在寄主转化中起关键作用。特别是在宿主转化期特异性检测到cut1基因转录本。这一结果表明，cut1可能是建立新的丝虫病感染控制策略的有效药物靶点。

项目成果

Furrowed/CTLSE1 aborts development of Plasmodium parasite in Anopheles gambiae

Furrowed/CTLSE1 阻止冈比亚按蚊疟原虫寄生虫的发育

• 发表时间: 2007
• 作者: 新澤直明;嘉糠洋陸;Kanuka H. et al.;Kanuka H. et al.;Nelson B. et al.;嘉糠洋陸;嘉糠洋陸;嘉糠洋陸;嘉糠洋陸
• 通讯作者: 嘉糠洋陸

Transcription-linked developmental transition in filarial parasites during a bridge between vector and host.

丝虫寄生虫在载体和宿主之间的桥梁期间的转录相关发育转变。

• 发表时间: 2009
• 作者: Aya Yoshimura;Kiyoshi Okado;Kazumasa Hada;Ryusuke Niwa;Shinya Fukumoto;Hirotaka Kanuka
• 通讯作者: Hirotaka Kanuka

Fly Immunity: Diversity of Drosophila Susceptibility to Bacterial Infection

苍蝇免疫：果蝇对细菌感染易感性的多样性

• 发表时间: 2007
• 作者: 岡戸清;新澤直明;青沼宏佳;福本晋也;嘉糠洋陸
• 通讯作者: 嘉糠洋陸

Gene silencing of ribosomal protein P0 is lethal to the tick Haemaphysalis longicornis.

核糖体蛋白 P0 的基因沉默对于长角血蜱来说是致命的。

• 发表时间: 2008
• 期刊: Vet.Parasitol. 第151巻
• 作者: Gong H;Liao M;Zhou J;Hatta T,Huan P;Zhang G;Kanuka H;Nishikawa Y;Xuan X;Fujisaki K
• 通讯作者: Fujisaki K

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