How acute stress modulates hemispheric asymmetries: Investigating the role of endocrinological and affective parameters

急性压力会影响大脑功能，但这些影响对左半球和右半球是否相似？半球不对称，例如左半球和右半球之间的性能差异，是人类大脑中的主要组织原则，并且是许多认知系统的基础。在多项研究中，大脑半球的不对称性已被证明会受到性类固醇激素的影响，最近的一项研究表明，与压力相关的类固醇激素（如糖皮质激素）也会影响它们。然而，另一种非激素假说也被提出来解释半球不对称和压力的关系，即压力产生的负面影响调节了半球不对称。计划中的项目的目的是系统地调查急性应激对半球不对称的影响。特别是，我们想检验心理神经内分泌假说。为此，将进行两项不同的研究。在研究1中，计划使用特里尔社会压力测试（TSST），以调查急性应激对大脑半球间的传输，以及在语言和情绪处理的行为和电生理不对称的影响。在研究2中，计划以与研究1相同的范例研究皮质醇与安慰剂应用对性能的影响。在这两项研究中，情感和内分泌参数将被评估，并与半球不对称。这项研究是第一个系统的，理论驱动的调查机制的调制半球不对称的急性心理社会。

Acute stress influences brain function, but are these effects similar for the right and the left hemisphere? Hemispheric asymmetries, e.g. performance differences between the left and the right hemisphere, are a major organizational principle in the human brain and underlie many cognitive systems. Hemispheric asymmetries have been shown to be affected by sex steroid hormones in multiple studies, and a recent study suggested that stress-related steroid hormones (e.g. glucocorticoids) also affect them. However, an alternative, non-hormonal hypothesis for the relation of hemispheric asymmetries and stress has also been put forward, namely that negative affect generated by stress modulates hemispheric asymmetries. The aim of the planned project is to systematically investigate the impact of acute stress on hemispheric asymmetries. In particular, we want to test the psychoneuroendocrine hypothesis. To this end, two different studies will be conducted. In Study 1, it is planned to use the Trier Social Stress Test (TSST) to investigate the impact of acute stress on interhemispheric transfer as well as behavioral and electrophysiological asymmetries in language and emotion processing. In Study 2, it is planned to investigate the impact of cortisol vs. placebo application on performance in the same paradigms as in study 1. In both studies, affective and endocrinological parameters will be assessed and linked to hemispheric asymmetries. The proposed study is the first systematic, theory-driven investigation of the mechanisms underlying the modulation of hemispheric asymmetries by acute psychosocial