Cellular mechanisms of nociception and nociceptive modulation in lateral and medial thalamocortical circuits in mice (B10)

丘脑和皮质之间的相互联系在调节传入伤害性活动的流动以及自上而下调节疼痛处理方面发挥着重要作用。B10将建立在第一个资助期通过第六层感觉皮质抑制丘脑腹后外侧的发现，现在通过体内电生理学解决小鼠的细胞机制。这将使我们能够深入了解疼痛相关信号通过皮质-丘脑-皮质回路的层流信号传播，并能够在未来的慢性疼痛治疗中利用它们来优化特定的脑刺激范例。

Reciprocal connections between the thalamus and the cortex plan an important role in regulating the flow of incoming nociceptive activity as well as top-down modulation of pain processing. B10 will build on findings from the first funding period of suppression of the ventroposterolateral thalamus by layer 6 of the sensory cortex to now address cellular mechanisms via in vivo electrophysiology in mice. This will enable deep insights into laminar signal propagation of pain-related signals through cortico-thalamo-cortical circuits and enable harnessing them to optimize specific brain stimulation paradigms in the future therapy of chronic pain.