Molecular triggers for neuropathy and neural invasion in pancreatic ductal adenocarcinoma (P07)

神经侵袭(NI)是人类胰腺癌常见且临床上难以克服的问题，与胰腺癌患者的总体生存和剧烈疼痛显著相关。在实验研究中，镍还没有得到充分的模拟。我们在PDAC中开发并表征了新型的NI小鼠模型和器官培养装置。使用这些创新的工具，我们将探索触发小鼠PDAC中NI的分子，并将更深入地研究导致NI的分子机制。此外，我们将建立更快、更接近人类的神经侵入性模型，最终目标是在人类PDAC中靶向NI。

Neural invasion (NI) is frequent and clinically overwhelming problem in human pancreatic cancer, which associates with markedly worsened overall survival and severe pain in patients. NI has not yet been sufficiently modelled in experimental research. We developed and characterised novel mouse models and organoid culture setups of NI in PDAC. Using these innovative tools, we will explore the molecules that trigger NI in mouse PDAC and will delve deeper into the molecular mechanisms that give rise to NI. Furthermore, we will generate faster and more human-like, neuro-invasive models with the ultimate goal of targeting NI in human PDAC.