Contribution of cellular stress to RNA virus PAMP recognition (A12)

该项目解决了持久性RNA病毒如何不被先天免疫系统识别的根本问题。对同基因、持续性和急性狂犬病弹状病毒的分析为细胞应激传感器在病毒PAMP识别和诱导抗病毒反应中的作用提供了实验证据。在确定所涉及的应激类型后，将确定应激是否能够启动RLR传感器以更好地识别病毒RNA，或者是否产生内源性危险信号(DAMP)，从而在细胞激活中与病毒RNA协同作用。

This project addresses the fundamental question how persistent RNA viruses can go unrecognized by the innate immune system. The analysis of isogenic persistent and acute rabies rhabdoviruses provided experimental evidence for contribution of cellular stress sensors to virus PAMP recognition and induction of an antiviral response. Upon determination of the stress types involved it will be determined whether stress can prime RLR sensors for better recognition of viral RNA, or whether endogenous danger signals (DAMPs) are produced that synergize with viral RNA in cell activation.