Dissecting and exploiting radiation-imposed reprogramming and metastasis in PDAC (P15)

除了肿瘤细胞的内在因素，外在因素在辐射抵抗、肿瘤复发和转移中发挥作用。因此，我们将在不同的PDAC小鼠模型上，研究肿瘤微环境对放射抵抗的影响，并研究肿瘤放射治疗后的复发和转移。治疗目标将通过遗传和药理学方法与放射治疗相结合来确定和定向。这些靶向治疗概念应该为新的多模式临床治疗方法提供基础。

Next to tumor cell-intrinsic factors, extrinsic factors play a role in radioresistance, tumor relapse and metastasis. Therefore, we will determine the influence of the tumor microenvironment on the radioresistance and investigate tumor relapse and metastasis after radiation therapy in different PDAC mouse models. Therapeutic targets will be identified and targeted by genetic and pharmacological approaches in combination with radiotherapy. These targeted therapy concepts should provide the basis for novel multimodal clinical treatment approaches.