Temperature-driven regulation system of hypermucoviscosity in carbapenem-resistant Klebsiella pneumoniae

多药耐药高毒力克雷伯氏菌肺炎一直在不断发展，这导致严重的临床结果，并显著挑战其感染的现有化疗治疗。肺炎杆菌产生几种称为细菌素的抗微生物肽，其对密切相关的物种具有抗菌活性。细菌素被认为是K.肺炎毒力因子我们在180 K中鉴定了细菌素基因。pneumoniae物种复合体基因组，包括170个高粘膜粘性分离株，并研究了对50种菌株的抗菌活性，包括属于多个物种的抗微生物剂耐药生物体。这项研究已于4月11日被接受，并于5月8日发表在Microbiology Spectrum上：Le MN，Nguyen TH，Trinh VM，Nguyen TP，Kawada-Matsuo M，Kayama S，Sugai M，Komatsuzawa H。高粘滞性肺炎克雷伯菌复合菌产生细菌素的综合分析。微生物光谱2023年5月8日：e0086323。doi：10.1128/spectrum.00863-23。Epub先于Print。PMID：37154746。

Multidrug-resistant and hypervirulent K. pneumoniae has been continuously evolving, which causes severe clinical outcome and significantly challenges the available chemotherapeutic treatment for its infections.K. pneumoniae produces several kinds of antimicrobial peptides known as bacteriocins, which have antibacterial activity against closely-related species. Bacteriocins are considered one of K. pneumoniae virulence factors. We identified bacteriocin genes in 180 K. pneumoniae species complex genomes, including 170 hypermucoviscous isolates, and investigated the antibacterial activity against 50 strains, including antimicrobial-resistant organisms, belonging to multiple species. This study has been accepted on April 11th and published on May 8th in Microbiology Spectrum:Le MN, Nguyen TH, Trinh VM, Nguyen TP, Kawada-Matsuo M, Kayama S, Sugai M, Komatsuzawa H. Comprehensive Analysis of Bacteriocins Produced by the Hypermucoviscous Klebsiella pneumoniae Species Complex. Microbiol Spectr. 2023 May 8:e0086323. doi: 10.1128/spectrum.00863-23. Epub ahead of print. PMID: 37154746.