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Event segmentation and the activity of CA1 engram cells in segregated environments

Event segmentation and the activity of CA1 engram cells in segregated environments
事件分割和隔离环境中 CA1 印迹细胞的活动
批准号:
22K15236
负责人:
王 家暄
金额:
$2.25万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Early-Career Scientists
财政年份:
2022
资助国家:
日本
项目状态:
未结题
起止时间:
2022-04-01 至 2025-03-31

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中文摘要
翻译
为了了解空间隔离如何影响我们对空间的感知和记忆,当动物在具有不同地板纹理的开放平台上航行时,从小鼠海马区收集电生理信号。在“隔离”平台上,地板上有一个类似减速带的突出物将平台分成两半;而在“非隔离”平台上,存在一个长度和宽度相同的突出物,但没有隔离平台。在过去的一年里,我建造了配备多个可单独调节的四极管的超空间驱动器,并成功收集了5只小鼠的CA 1多单元信号。数据将被预处理和分析。
英文摘要
In order to understand how spatial segregation affects our perception and memory about a space, electrophysiological signal was collected from the hippocampal area of mouse when the animal was navigating open platforms with different floor textures. On the "segregated" platform, a speed bump-like protrusion on the floor segregated the platform into two halves; while on the "non-segregated" platform, a protrusion with identical length and width existed but did not segregate the platform.In the past year, I built hyperdrives equipped with multiple individually-adjustable tetrodes and successfully collected CA1 multiunit signals from 5 mice. The data are to be preprocessed and analyzed.
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