Role of platelets in tissue remodelling and functional recovery after experimental cerebral ischaemia (B04+)
Role of platelets in tissue remodelling and functional recovery after experimental cerebral ischaemia (B04+)
批准号:
406447995
负责人:
金额:
$0.0万
依托单位:
依托单位国家:
德国
项目类别:
CRC/Transregios
财政年份:
2018
资助国家:
德国
项目状态:
已结题
起止时间:
2017-12-31 至 2021-12-31
中文摘要
在B04,我们将评估血小板在卒中后恢复和晚期组织重塑过程中是否起到病理生理作用。主要的焦点将集中在血小板介导的血栓炎症以及血小板的潜在血管外效应,例如诱导细胞凋亡。具有翻译意义的小鼠模型、新型药理抑制剂和先进的成像技术将被用来研究我们的研究问题。
英文摘要
In B04, we will assess whether platelets play a pathophysiological role during post-stroke recovery and late-stage tissue remodelling. The main focus will be on platelet-mediated thrombo-inflammation as well as potential extravascular effects of platelets, e.g. induction of apoptosis. Translationally meaningful mouse models, novel pharmacological inhibitors, and advanced imaging techniques will be used to investigate our research questions.
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