Organocatalytic Cycloaddition Reactions and Mechanistic Investigations

在众多的有机催化反应中，亲核有机催化剂催化的环加成反应因其反应效率高、反应条件温和、催化剂易回收而成为最常用和最有效的碳杂环化合物合成方法之一。然而，导致高区域和立体选择性的机制仍然缺乏系统的研究。在这个中德联合研究项目中，我们打算用实验和理论相结合的方法研究有机催化环加成反应及其相关机理，并进一步开发新的反应模式，探索新的底物和机理，这将有助于合成天然产物的核心结构。预计有关研究小组的方法多样性将提供特别高的协同增效作用。

Among a large number of organocatalytic reactions, cycloaddition reactions catalyzed by nucleophilic organocatalysts have been well developed, since they represent one of the most commonly used and efficient methods to access carbo- and heterocyclic compounds due to their high efficiency, very mild reaction conditions, and easy recycling of catalysts. However, the mechanisms leading to high regio- and stereoselectivities still lack systematic research. Within this Joint Sino-German Research Project, we intend to investigate organocatalytic cycloaddition reactions and their related mechanisms using a combination of experimental and theoretical techniques, and further to develop new reaction modes and to explore new substrates and mechanisms, which will benefit the synthesis of core structures of natural products. The methodological diversity of the involved research groups is expected to offer particularly high synergies.