Identification of oropharyngeal and craniofacial risk factors in obstructive sleep apnea.

在影响人类健康的许多睡眠障碍中，阻塞性睡眠呼吸暂停综合征（OSAS）在普通人群中具有最高的患病率之一，并且是发病率、死亡率和生活质量受损的主要原因。目前的研究指出，阻塞性睡眠呼吸暂停是由于结构和功能异常导致睡眠时上呼吸道反复塌陷的结果，而肥胖、肥胖、睡眠呼吸暂停综合征、睡眠呼吸暂停综合征、睡眠呼吸口咽结构解剖学和颅面形态学是该疾病的存在和严重性的关键决定因素。在这个项目中，我们将调查构成阻塞性睡眠呼吸暂停发展的重要危险因素的解剖学和形态学方面。我们将利用磁共振图像，国家的最先进的方法结合多导睡眠图的结果，从一个大样本的主题，提供可靠的定量口咽结构和人体测量的颅面复合体，我们将使用建立一个综合的预测模型阻塞性睡眠呼吸暂停的严重程度。

Among the many sleep disorders affecting human health, obstructive sleep apnea syndrome (OSAS) has one of the highest prevalence rates in the general population and is a major cause of morbidity, mortality and impaired quality of life. Despite the increase in the number of diagnostic modalities, the majority of those affected remains undiagnosed and there is an increased need to understand OSAS pathogenesis in the general population.The current research points out that obstructuve sleep apnea is the result of structural and functional abnormalities that promote repetitive collapse of the upper airway during sleep, and that factors, such as obesity, oropharyngeal structures anatomy and craniofacial morphology are key determinants to the presence and severity of the disorder. In this project, we will investigate the anatomical and morphological aspects that constitute important risk factors to obstructive sleep apnea development. We will utilize magnetic resonance images, state-of-the-art methods in combination with polysomnographic findings from a large sample of subjects to provide reliable quantifications of oropharyngeal structures and anthropometric measurements of the craniofacial complex, which we will use to establish an integrated predictive model of obstructive sleep apnea severity.