Role of prolyl-hydroxylase domain enzyme inhibitors in chronic renal inflammation (B05)

抑制Pro羟基酶结构域酶(PHDI)对慢性肾小管间质炎症依赖肾病模型小鼠的保护作用。PHDI介导的保护需要单核吞噬细胞的存在。此外，PHDI还可阻断单核巨噬细胞Caspase-1依赖的IL-1β的释放。为了验证单核巨噬细胞的PHDI是否能改善慢性肾炎，我们将对单核巨噬细胞亚群在慢性炎症性肾病发病机制中的作用及其在PHDI介导的保护作用中的作用进行表征和分析。此外，我们将破译PHDI治疗如何损害单核吞噬细胞中IL-1β的释放。

Inhibition of prolyl hydroxylase domain enzymes (PHDi) protects mice in a model of chronic tubulointerstitial inflammasome-dependent kidney disease. PHDi-mediated protection required the presence of mononuclear phagocytes. Moreover, PHDi blocked caspase-1-dependent IL-1β release in mononuclear phagocytes. In order to test whether PHDi in mononuclear phagocytes ameliorates chronic nephritis we will characterize and analyze the contribution of subsets of mononuclear phagocytes in the pathogenesis of chronic inflammatory kidney diseases and their role in PHDi-mediated protection. Moreover, we will decipher how PHDi-treatment impairs IL-1β release in mononuclear phagocytes.