The role of hypoxia response system in the development of cardiovascular and metabolic diseases

缺氧反应系统在心血管及代谢疾病发生发展中的作用

• 批准号: 23659421
• 负责人: SUNAGAWA Kenji
• 金额: $ 2.33万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659421/
• 关键词: 分子血管病態学; 低酸素応答系; 生活習慣病; prolyl hydroxylase; 脂肪細胞; 耐糖能; 肥満; hypoxia-inducible factor; アンジオテンシンII受容体; 細胞肥大; 線維化

Inhibition of prolyl hydorxlyase (PHD), an oxygen sensor, suppressed anigotensin II receptor expression in vascular smooth muscle cells and angiotensin II-induced cardiac fibrosis. Mice with targeted deletion of PHD isoform 2 in adipocytes were resistant to high-fat diet-induced obesity and glucose intolerance. PHD inhibition may be a novel strategy for the treatment of cardiovascular diseases and metabolic syndrome.

抑制脯氨酸水解酶（一种氧传感器）可抑制血管平滑肌细胞中的抗血管紧张素II受体表达和血管紧张素II诱导的心脏纤维化。在脂肪细胞中靶向删除PHD亚型2的小鼠对高脂肪饮食诱导的肥胖和葡萄糖耐受不良具有抗性。抑制PHD可能是治疗心血管疾病和代谢综合征的新策略。

项目成果

Beraprost sodium, a stable prostacyclin analogue, improves insulin resistance in high-fat diet-induced obese mice

• DOI: 10.1530/joe-12-0014
• 发表时间: 2012-06-01
• 期刊: JOURNAL OF ENDOCRINOLOGY
• 影响因子: 4
• 作者: Inoue, Eriko;Ichiki, Toshihiro;Sunagawa, Kenji
• 通讯作者: Sunagawa, Kenji

Prolyl Hydroxylase Domain Protein 2 Plays a Critical Role in Diet-Induced Obesity and Glucose Intolerance

• DOI: 10.1161/circulationaha.113.001742
• 发表时间: 2013-05-28
• 期刊: CIRCULATION
• 影响因子: 37.8
• 作者: Matsuura, Hirohide;Ichiki, Toshihiro;Sunagawa, Kenji
• 通讯作者: Sunagawa, Kenji

Adipocyte-Specific Deletion of Prolyl Hydroxylase Domain Protein 2 Ameliorates Diet-induced Obesity and Glucose Intolerance in Mice

脂肪细胞特异性删除脯氨酰羟化酶结构域蛋白 2 可改善小鼠饮食诱导的肥胖和葡萄糖不耐受

• 发表时间: 2012
• 作者: Hirohide Matsuura;Toshihiro Ichiki; Kotaro Takeda;Kenji Sunagawa
• 通讯作者: Kenji Sunagawa

Prolyl hydroxylase domain 蛋白の阻害はアンジオテンシンIIタイプ１受容体の発現を抑制する

抑制脯氨酰羟化酶结构域蛋白可抑制血管紧张素 II 1 型受体的表达

• 发表时间: 2011
• 作者: Satoh K;Fukumoto Y;Sugimura K;Miura Y;Nochioka K;Aoki T;Tatebe S;Yamamoto S;Osaki S;Takagi Y;Tsuburaya R;Itoh Y;Matsumoto Y;Nakayama M;Takeda M;Takahashi J;Itoh K;Yasuda S;Shimokawa H;松浦広英
• 通讯作者: 松浦広英

Inhibition of Prolyl Hydroxylase Domain Protein Downregulates Vascular Angiotensin II Type 1 Receptor

脯氨酰羟化酶结构域蛋白的抑制下调血管紧张素 II 1 型受体

• 发表时间: 2012
• 作者: Hirohide Matsuura;Toshihiro Ichiki; Kotaro Takeda;Kenji Sunagawa
• 通讯作者: Kenji Sunagawa