Horizontal transfer, evolution, and cellular integration of Staphylococcus antibiosis islands (SAbIs) (B04)

我们最近描述了葡萄球菌能产生多种抗菌化合物。负责的基因簇显示出移动性的迹象，我们建议将其命名为SABIS。我们将确定SABIS的家族，并调查SABI转移的途径和频率。利用体外进化实验和代谢组学/基因组学方法，我们将研究调节生产者抗性的适应过程和优化Sabi受体适合性的代谢通量。该项目将对生理和代谢瓶颈以及相关的适应提供新的见解，塑造细菌群落中产生的化合物的多样性。

We recently described that staphylococcal species produce a variety of antibacterial compounds. The responsible gene clusters show signs of mobility and we suggest to term them SAbIs. We will identify families of SAbIs and investigate the routes and frequency of SAbI transfer. Using in vitro evolution experiments and metabolomics/genomics approaches, we will investigate adaptation processes that mediate producer resistance and metabolic fluxes that optimize fitness in SAbI recipients. The project will deliver novel insights into physiologic and metabolic bottlenecks as well as associated adaptations, shaping the diversity of compounds produced within bacterial communities.