Defining key principles of late small ribosomal subunit assembly in archaea (B13*)

该项目提案旨在功能表征古细菌特异性和保守的细菌和真核生物样特征在古细菌中合成小核糖体亚基的最新步骤所需的可能相互作用。为此，我们的目标是在功能上描述小核糖体亚基形成的最后步骤所需的选定的关键反式和顺式作用因子。因此，该项目提案有助于定义古细菌体内核糖体组装途径的关键原理，并阐明核糖体组装过程的复杂进化关系。

This project proposal aims to functionally characterise the possible interplay of archaeal specific and conserved bacterial- and eukaryote-like features required for the latest steps of small ribosomal subunit synthesis in archaea. To do so, we aim to functionally characterise selected putative key trans- and cis-acting factors required for the last steps of small ribosomal subunit formation.Accordingly, this project proposal contributes to the definition of key principles of the in vivo ribosome assembly pathway in archaea and shed light on the intricate evolutionary relationship of the ribosome assembly processes.