Virulence determinants influencing re-emergence of a complex RNA virus

该项目旨在研究自然发生的重组体中的特定基因对它们引起疾病和在鸡之间传播的能力的影响。冠状病毒是世界范围内家畜的主要病原体。鸡冠状病毒传染性支气管炎病毒的反复出现与野生型病毒和疫苗病毒之间的重组有关，但影响这一点的因素，特别是来自疫苗病毒的基因赋予这些重组体的选择优势，尚不清楚。该项目的最终目的是确定新的疫苗和替代管理策略，以减少这种病毒和其他冠状病毒重新出现的频率。

This project intends to examine the effects that specific genes in naturally occurring recombinants have on their capacity to cause disease and spread between chickens. Coronaviruses are major pathogens of domestic animals throughout the world. Recurrent re-emergence of the coronavirus of chickens, infectious bronchitis virus, has been associated with recombination between wild type viruses and vaccine viruses, but the factors influencing this, and in particular the selective advantages genes from vaccine viruses confer on these recombinants, are unknown. The ultimate aim of the project is to identify both novel vaccines and alternative management strategies that might reduce the frequency of re-emergence of this virus and other coronaviruses.