Multilevel factors influencing racial, ethnic, and socioeconomic disparities in hidradenitis suppurativa

项目摘要/摘要 化脓性汗腺炎是一种慢性炎症性疾病，以疼痛，反复发作的皮肤脓肿，囊肿， 引流鼻窦道，留下难看的疤痕。化脓性汗管炎不成比例地影响种族和 少数民族。尽管人们意识到了这些差距，但根本原因并没有 经过充分的研究。张博士正在寻求NIH K23指导下的以患者为导向的研究生涯 获得必要的指导培训、实践经验和知识的发展奖 成为慢性炎症性皮肤健康差异的独立资助临床调查员 以化脓性汗腺炎为重点的疾病。为了实现这一目标，该应用程序的总体目标是 确定个人层面、人际层面和社区层面影响汗腺炎的因素 化脓性传染病的流行病学和结果。理解这些多层次的因素及其相互作用是 对促进我们对化脓性汗腺炎的理解和设计有效的干预措施至关重要 加强化脓性汗腺炎的管理。张博士建议：1)使用大型种族和 不同的社会经济学数据集，以确定化脓性汗腺炎患病率的差异 个人层面和社区层面的因素，并评估个人层面和社区层面因素之间的关联 社区层面的因素和化脓性汗腺炎的生物治疗；2)评估个人-， 通过开展一项与诊断时间相关的人际和社区层面因素的调查研究 种族和社会经济上不同的成年人患有化脓性汗腺炎；3)确定患者报告 使用混合方法获得化脓性汗腺炎护理的促进者 社会经济多元化的研究参与者。一个拥有多学科专业知识的指导团队将指导Dr。 张的事业发展和研究进展：免疫介导性疾病(Yazdany博士)，汗腺炎 SupPurativa(奈克和利诺斯博士)，观察性研究的流行病学方法(雅兹达尼和利诺斯博士)， 健康差异研究(亚兹达尼和阿克曼博士)、定性/混合方法研究(阿克曼博士 和Linos)。他们的指导结合有重点的培训和拟议的研究计划将培养Dr。 张在慢性炎症性疾病的健康差异研究方面的专业知识。

PROJECT SUMMARY/ABSTRACT Hidradenitis suppurativa is a chronic inflammatory disease marked by painful, recurrent skin abscesses, cysts, draining sinus tracts, and disfiguring scarring. Hidradenitis suppurativa disproportionately affects racial and ethnic minority groups. Despite an awareness of these disparities, the underlying causes have not been adequately studied. Dr. Chang is seeking an NIH K23 Mentored Patient-Oriented Research Career Development Award to acquire the necessary mentored training, practical experience, and knowledge to become an independently funded clinical investigator of health disparities in chronic inflammatory skin diseases with a focus on hidradenitis suppurativa. Towards this goal, the overall objective of this application is to identify individual-level, interpersonal-level, and community-level factors that influence hidradenitis suppurativa epidemiology and outcomes. Understanding these multilevel factors and their interactions is pivotal for advancing our understanding of hidradenitis suppurativa and designing effective interventions to improve hidradenitis suppurativa management. Dr. Chang proposes to: 1) Use a large racially and socioeconomically diverse dataset to identify differences in hidradenitis suppurativa prevalence based on individual-level and community-level factors and to evaluate the association between individual-level and community-level factors and receiving biologic therapy for hidradenitis suppurativa; 2) Assess individual-, interpersonal-, and community-level factors associated with time to diagnosis by conducting a survey study of racially and socioeconomically diverse adults living with hidradenitis suppurativa; 3) Identify patient-reported facilitators of obtaining care for hidradenitis suppurativa using a mixed methods approach with racially and socioeconomically diverse study participants. A mentoring team with multidisciplinary expertise will guide Dr. Chang's career development and research progress: immune-mediated diseases (Dr. Yazdany), hidradenitis suppurativa (Drs. Naik and Linos), epidemiologic methods for observational studies (Drs. Yazdany and Linos), health disparities research (Drs. Yazdany and Ackerman), qualitative/mixed methods research (Drs. Ackerman and Linos). Their mentorship combined with focused training and the proposed research plan will develop Dr. Chang's expertise in health disparities research in chronic inflammatory diseases.