Multilevel factors influencing racial, ethnic, and socioeconomic disparities in hidradenitis suppurativa

影响化脓性汗腺炎种族、民族和社会经济差异的多层次因素

基本信息

批准号：
10721135
负责人：
Aileen Yenting Chang
金额：
$ 16.73万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-15 至 2028-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10721135
关键词：
Address Adult Affect Age Awareness Biological Biological Response Modifier Therapy Biometry Black race California Caring Cicatrix Clinic Clinical Clinical Investigator Collection Communities County Cyst Data Data Set Data Sources Dermatologist Dermatology Development Development Plans Diagnosis Disease Disease Outcome Disparity Economics Environment Epidemiologic Methods Epidemiology Ethnic Origin Evaluation FDA approved Family Foundations Funding Future Generations Goals Health Health Disparities Research Health Services Accessibility Health behavior Health system Hidradenitis Suppurativa Hispanic Immune Individual Institution Intervention Knowledge Mediating Medical Mentored Patient-Oriented Research Career Development Award Mentors Mentorship Methods Modeling National Institute on Minority Health and Health Disparities Neighborhoods Observational Study Outcome Pain Participant Patient Outcomes Assessments Patient-Focused Outcomes Patients Persons Pharmaceutical Preparations Population Prevalence Process Provider Public Health Public Hospitals Race Recurrence Reporting Research Research Methodology Research Proposals Rural Community Rural Population Sampling San Francisco Severities Severity of illness Shapes Sinus Site Socioeconomic Status Structure Surveys Techniques Time Training United States United States National Institutes of Health Universities Urban Community Work career development chronic inflammatory disease chronic inflammatory skin cohort community-level factor data de-identification data repository design diverse data economic determinant effective intervention ethnic minority ethnic minority population evidence base experience health data health disparity improved improved outcome indexing inhibitor therapy innovation low socioeconomic status minority patient multidisciplinary racial diversity racial minority racial minority population research and development sex skills skin abscess skin disorder social culture social health determinants sociodemographics socioeconomic disparity socioeconomics study population therapy development tumor necrosis factor-alpha inhibitor

项目摘要

PROJECT SUMMARY/ABSTRACT Hidradenitis suppurativa is a chronic inflammatory disease marked by painful, recurrent skin abscesses, cysts, draining sinus tracts, and disfiguring scarring. Hidradenitis suppurativa disproportionately affects racial and ethnic minority groups. Despite an awareness of these disparities, the underlying causes have not been adequately studied. Dr. Chang is seeking an NIH K23 Mentored Patient-Oriented Research Career Development Award to acquire the necessary mentored training, practical experience, and knowledge to become an independently funded clinical investigator of health disparities in chronic inflammatory skin diseases with a focus on hidradenitis suppurativa. Towards this goal, the overall objective of this application is to identify individual-level, interpersonal-level, and community-level factors that influence hidradenitis suppurativa epidemiology and outcomes. Understanding these multilevel factors and their interactions is pivotal for advancing our understanding of hidradenitis suppurativa and designing effective interventions to improve hidradenitis suppurativa management. Dr. Chang proposes to: 1) Use a large racially and socioeconomically diverse dataset to identify differences in hidradenitis suppurativa prevalence based on individual-level and community-level factors and to evaluate the association between individual-level and community-level factors and receiving biologic therapy for hidradenitis suppurativa; 2) Assess individual-, interpersonal-, and community-level factors associated with time to diagnosis by conducting a survey study of racially and socioeconomically diverse adults living with hidradenitis suppurativa; 3) Identify patient-reported facilitators of obtaining care for hidradenitis suppurativa using a mixed methods approach with racially and socioeconomically diverse study participants. A mentoring team with multidisciplinary expertise will guide Dr. Chang's career development and research progress: immune-mediated diseases (Dr. Yazdany), hidradenitis suppurativa (Drs. Naik and Linos), epidemiologic methods for observational studies (Drs. Yazdany and Linos), health disparities research (Drs. Yazdany and Ackerman), qualitative/mixed methods research (Drs. Ackerman and Linos). Their mentorship combined with focused training and the proposed research plan will develop Dr. Chang's expertise in health disparities research in chronic inflammatory diseases.

项目摘要/摘要 Hidradenenitis Purpurativa是一种慢性炎症性疾病，以疼痛，复发性皮肤脓肿，囊肿，，囊肿，排出鼻窦片，毁容疤痕。 Hidradenitis purpurativa不成比例地影响种族和少数民族群体。尽管意识到这些差异，但根本原因并非充分研究了。 Chang博士正在寻求NIH K23以患者为导向的研究职业开发奖，以获得必要的受过指导培训，实践经验和知识成为慢性炎症性皮肤健康差异的独立资助的临床研究者疾病的重点是Hidradenitis purativa。朝向这个目标，此应用程序的总体目标是确定影响Hidradenitis的个人级别，人际关系和社区级别的因素修剪的流行病学和结果。了解这些多层次因素及其相互作用是关键是我们促进我们对Hidradenitis Purpurativa的理解并设计有效的干预措施改善Hidradenenitis Purpurativa管理。 Chang博士提议：1）在种族上使用大型社会经济多样化的数据集，以确定基于个人级别和社区级别的因素，并评估个人级别与社区水平的因素和接受Hidradenenitis spurativa的生物疗法； 2）评估个人 - 通过进行针对诊断时间相关的人际交往和社区级别的因素，通过进行调查研究种族和社会经济多样化的成年人，患有Hidradenitis spurativa； 3）确定患者报告使用种族和种族和社会经济多样的研究参与者。具有多学科专业知识的指导团队将指导博士。 Chang的职业发展和研究进度：免疫介导的疾病（Yazdany博士），Hidradenitis Purativa（Naik和Linos博士），观察性研究的流行病学方法（Yazdany和Linos博士），健康差异研究（Yazdany和Ackerman博士），定性/混合方法研究（Ackerman博士和linos）。他们的指导与重点培训相结合，拟议的研究计划将制定博士。 Chang在慢性炎症性疾病方面的健康差异研究方面的专业知识。