Multilevel factors influencing racial, ethnic, and socioeconomic disparities in hidradenitis suppurativa

影响化脓性汗腺炎种族、民族和社会经济差异的多层次因素

• 批准号: 10721135
• 负责人: Aileen Yenting Chang
• 金额: $ 16.73万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-15 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10721135
• 关键词: Address; Adult; Affect; Age; Awareness; Biological; Biological Response Modifier Therapy; Biometry; Black race; California; Caring; Cicatrix; Clinic; Clinical; Clinical Investigator; Collection; Communities; County; Cyst; Data; Data Set; Data Sources; Dermatologist; Dermatology; Development; Development Plans; Diagnosis; Disease; Disease Outcome; Disparity; Economics; Environment; Epidemiologic Methods; Epidemiology; Ethnic Origin; Evaluation; FDA approved; Family; Foundations; Funding; Future; Generations; Goals; Health; Health Disparities Research; Health Services Accessibility; Health behavior; Health system; Hidradenitis Suppurativa; Hispanic; Immune; Individual; Institution; Intervention; Knowledge; Mediating; Medical; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Methods; Modeling; National Institute on Minority Health and Health Disparities; Neighborhoods; Observational Study; Outcome; Pain; Participant; Patient Outcomes Assessments; Patient-Focused Outcomes; Patients; Persons; Pharmaceutical Preparations; Population; Prevalence; Process; Provider; Public Health; Public Hospitals; Race; Recurrence; Reporting; Research; Research Methodology; Research Proposals; Rural Community; Rural Population; Sampling; San Francisco; Severities; Severity of illness; Shapes; Sinus; Site; Socioeconomic Status; Structure; Surveys; Techniques; Time; Training; United States; United States National Institutes of Health; Universities; Urban Community; Work; career development; chronic inflammatory disease; chronic inflammatory skin; cohort; community-level factor; data de-identification; data repository; design; diverse data; economic determinant; effective intervention; ethnic minority; ethnic minority population; evidence base; experience; health data; health disparity; improved; improved outcome; indexing; inhibitor therapy; innovation; low socioeconomic status; minority patient; multidisciplinary; racial diversity; racial minority; racial minority population; research and development; sex; skills; skin abscess; skin disorder; social culture; social health determinants; sociodemographics; socioeconomic disparity; socioeconomics; study population; therapy development; tumor necrosis factor-alpha inhibitor

PROJECT SUMMARY/ABSTRACT Hidradenitis suppurativa is a chronic inflammatory disease marked by painful, recurrent skin abscesses, cysts, draining sinus tracts, and disfiguring scarring. Hidradenitis suppurativa disproportionately affects racial and ethnic minority groups. Despite an awareness of these disparities, the underlying causes have not been adequately studied. Dr. Chang is seeking an NIH K23 Mentored Patient-Oriented Research Career Development Award to acquire the necessary mentored training, practical experience, and knowledge to become an independently funded clinical investigator of health disparities in chronic inflammatory skin diseases with a focus on hidradenitis suppurativa. Towards this goal, the overall objective of this application is to identify individual-level, interpersonal-level, and community-level factors that influence hidradenitis suppurativa epidemiology and outcomes. Understanding these multilevel factors and their interactions is pivotal for advancing our understanding of hidradenitis suppurativa and designing effective interventions to improve hidradenitis suppurativa management. Dr. Chang proposes to: 1) Use a large racially and socioeconomically diverse dataset to identify differences in hidradenitis suppurativa prevalence based on individual-level and community-level factors and to evaluate the association between individual-level and community-level factors and receiving biologic therapy for hidradenitis suppurativa; 2) Assess individual-, interpersonal-, and community-level factors associated with time to diagnosis by conducting a survey study of racially and socioeconomically diverse adults living with hidradenitis suppurativa; 3) Identify patient-reported facilitators of obtaining care for hidradenitis suppurativa using a mixed methods approach with racially and socioeconomically diverse study participants. A mentoring team with multidisciplinary expertise will guide Dr. Chang's career development and research progress: immune-mediated diseases (Dr. Yazdany), hidradenitis suppurativa (Drs. Naik and Linos), epidemiologic methods for observational studies (Drs. Yazdany and Linos), health disparities research (Drs. Yazdany and Ackerman), qualitative/mixed methods research (Drs. Ackerman and Linos). Their mentorship combined with focused training and the proposed research plan will develop Dr. Chang's expertise in health disparities research in chronic inflammatory diseases.

项目总结/摘要 化脓性汗腺炎是一种慢性炎症性疾病，其特征是疼痛、复发性皮肤脓肿、囊肿， 引流窦道和毁容疤痕化脓性汗腺炎不成比例地影响种族和 少数民族群体。尽管认识到这些差距，但其根本原因尚未得到充分的认识。 充分研究。Chang博士正在寻求NIH K23指导的以患者为导向的研究职业 发展奖获得必要的指导培训，实践经验和知识， 成为一个独立资助的慢性炎症皮肤健康差异的临床研究者 以化脓性汗腺炎为重点的疾病。为了实现这一目标，本申请的总体目标是 确定影响汗腺炎的个人水平、人际水平和社区水平因素 化脓性脑膜炎流行病学和结果。了解这些多层次因素及其相互作用， 对于促进我们对化脓性汗腺炎的理解和设计有效的干预措施， 加强化脓性汗腺炎管理。张博士建议：1）使用一个大的种族和 社会经济多样性数据集，以确定化脓性汗腺炎患病率的差异， 个人水平和社区水平的因素，并评估个人水平和 社区水平的因素和接受化脓性汗腺炎的生物治疗; 2）评估个人， 人际关系和社区水平的因素与诊断时间相关，通过进行一项调查研究， 患有化脓性汗腺炎的种族和社会经济多样化的成年人; 3）确定患者报告的 促进获得护理化脓性汗腺炎使用混合方法的方法与种族和 社会经济多样化的研究参与者。一个具有多学科专业知识的指导小组将指导博士。 Chang的职业发展和研究进展：免疫介导的疾病（Yazdany博士），汗腺炎 化脓性（Naik和Linos博士），观察性研究的流行病学方法（Yazdany和Linos博士）， 健康差异研究（Yazdany和阿克曼博士）、定性/混合方法研究（阿克曼博士 Linos）。他们的指导结合重点培训和拟议的研究计划将发展博士。 Chang在慢性炎症性疾病的健康差异研究方面的专长。