Studies on the Inhibitory Effect of Blood Transfusion Against Anti-Tumor Immunity

为了分析输血作用的机制，我们进行了小鼠体内存活率的实验研究。接受异基因输血的小鼠的存活率明显低于同基因输血或生理盐水对照组(C57BL/10：P&lt；0.05，BALB/C：P&lt；0.01)。与输注血浆或红细胞相比，输注淋巴细胞可降低存活率(P&lt；0.05)。另一方面，在体外实验中，无论是抗X5563 CTL(P&lt；0.05)、TNP-CTL(P&lt；0.01)或NK(P&lt；0.05)，GREOP与同种异体输注组相比均显著低于对照组和同基因输注组。此外，我们还证明了CTL活性的抑制是由抑制细胞介导的。

To analyze the mechanism on the effect of blood transfusion, we studied on survival rate in mice in vivo experiments. Mice that received allogenic blood had significantly worse survival rate than either syngenic-transfuued or saline-infused control groups (C57BL/10 : p<0.05, BALB/C : p<0.01). A transfusion of lymphocytes reduced survival rate in comparison with a transfusion of plasma or RBC (P<0.05). On the other hand, in vitro experiments, the responses of the greop transfused with allogenic donors were significantly lower than responses of control or syngenic transfused group, in either anti-X5563 CTL (P<0.05), TNP-CTL (p<0.01), or NK (p<0.05). Furthermore, we demonstrated that the suppression of CTL activity was mediated by suppressor cells.