BASIC STUDY ON TRADITIONAL MEDICINES HAVING SEDATIVE EFFECT FOR SEARCH OF NEUROTROPIC DRUG-MATERIAL

对南亚、南美地区常用的中药和药用植物进行了药理学分析。从一些具有活性的药用植物中，采用活性引导法分离出这些原理。进一步测试活性化合物的其他药理作用，以阐明其药理性质。经鉴定，日本中成药心木香和切牙白土的活性成分分别为-海木香-8（14）、15-二烯-19-oic酸，以及-山楂-16-en-19-oic酸和notopterol。研究了这些化合物与当归中蛇床子酚的药理差异。婆罗洲药用植物少花塔伯纳（tabernamontana pauciflora）和熊猫金猴（T.pandacaqui）以冠状苯胺、空甘碱等吲哚类生物碱为镇痛原理，具有降体温作用，但对运动活性无影响。秘鲁药用植物Chenopodium ambrosioides和Lipia triphylla的镇静和镇痛成分分别为ascaridole和acteoside。通过对相关化合物的镇痛活性比较，得到了毛蕊花苷的活性结构信息。本研究得出了一些传统药物和药用植物具有镇静作用的化学和药理学基础。

pharmacological assay of traditional medicines and medicinal plants which have been used as narvine, analgesia, anxiolytic in South Asia and South America was done. From some midicinal plants showing activity, the principles were isolated by activity-guided procedure. The active compounds were furthermore tested for the other pharmacological effects to clarify their pharmacological properties.The active principles of Aralia cordata and Notopterygium incisum, Japanese-Chinese medicines, were identified as ent-pimara-8(14), 15-dien-19-oic acid and ent-kaur-16-en-19-oic acid and notopterol, respectively. These compounds and osthol from Angelica pubescens were examined to discuss for their pharmacological differences. Tabernaemontana pauciflora and T.pandacaqui, Bornean medicinal plants gave indole-alkaloids such as coronaridine, voacangine as analgesic principles which showed hypothermic effect but no effect on locomotor activity. The sedative and analgesic components of Peruvian medicinal plants, Chenopodium ambrosioides and Lipia triphylla were found to be ascaridole and acteoside, respectively. The information on the active structure of acteoside was also obtained by comparison of the analgesic activity of the related compounds.This investigation resulted in the chemical and pharmacological basis on the efficacy of some traditional medicines and medicinal plants having sedation.