A long term follow-up study of first-break schizophrenics : Outcome and social, psychological and biological factors

本文对初发精神分裂症患者的预后与社会、心理和生物学因素的关系进行了长期随访研究，结果表明：（1）初发精神分裂症患者在入院后10年内死亡5例，死亡率为4.7%。(2)职业：43%的原始受试者是受雇者、自营职业者或家庭主妇。(3)婚姻状况：已婚者占23%。男性的结婚率低于女性，离婚率高于女性。(4)经济水平：与首次接触时相比，10年随访时高于平均水平的等级减少。(5)社会结果和遗传：结果良好组与不良组的生身父母精神障碍差异无统计学意义，但精神分裂症、抑郁症等重性精神病仅见于不良组。(6)PSE-9的CATEGO分级：预后良好组S级病例较多，但无统计学意义。(7)儿童期和/或青春期的社会结局和适应不良史：不良结局组的适应不良评分高于良好结局组。(8)临床病程：最常见的病程类型是精神病复发，复发之间不完全缓解。

The findings obtained in this long term follow-up research on the relation between outcome of first-break schizophrenics and social, psychological and biological factors are as follows;(1) Five subjects were dead during 10 years after first contact with psychiatric facility and the rate of death in all subjects was 4.7%.(2) Occupation: Forty-three percent of original subjects was employed, self-employed or housewife.(3) Marital state: The percentage of those got married was 23%. Male subjects had lower marriage rate and higher divorce rate than female subjects.(4) Economical level: Higher than average class decreased at the time of 10-year follow-up in comparison with the time of first contact.(5) Social outcome and heredity: No significant difference was found in mental disorders of biological parents between good and poor outcome group, however major psychoses such as schizophrenia or depression were found only in the latter group.(6) CATEGO class of PSE-9: There were more cases with class S in good outcome group without statistical significance.(7) Social outcome and history of maladjustment in childhood and/or in adolescence: More positive ratings of maladjustment in poor outcome group than in good outcome group.(8) Clinical course: The most frequent type of course was those with psychotic relapses with incomplete remission between relapses.