Intravenous anesthetics and epinephrine-induced arrhythmias.

1.众所周知，氟烷等碳氢化合物麻醉剂可增强肾上腺素诱发的心律失常。关于静脉麻醉药，有报道称硫喷妥钠比氟烷更能增强肾上腺素诱发的心律失常。然而，其他静脉麻醉药对肾上腺素诱发的心律失常的影响还没有得到很好的讨论。本研究旨在阐明异丙酚和依托咪酯对肾上腺素诱发的犬心律失常的影响。结果表明，异丙酚增强肾上腺素诱发的心律失常，而依托咪酯对肾上腺素诱发的心律失常无明显影响。此外，在依托咪酯存在的背景下，我们确定了异丙酚的作用是剂量依赖的。(麻醉学，1991)2.硫喷妥可使心脏对肾上腺素的致心律失常作用敏感，但硫喷妥钠致心律失常的肾上腺素受体机制尚不清楚。我们比较了α和β肾上腺素能受体在硫喷妥钠致心肌增敏中的作用，证明了α和β肾上腺素能受体活动在硫喷妥钠致心律失常的心肌增敏中起重要作用。为了进一步研究肾上腺素诱发心律失常的肾上腺素受体机制，我们利用氟烷麻醉犬设计了一种实验模型来阐明β1和β2肾上腺素受体的作用。(Can J Anaesth，1992)在我们的下一项工作中，我们打算使用这个实验模型来阐明β受体亚型在硫喷妥钠麻醉期间心律失常发生中的作用。

1. It is well known that halothane and other hydrocarbon anesthetics enhance the epinephrine-induced arrhythmias. Regarding to intravenous anesthetics, thiopental has been reported to enhance the epinephrine-induced arrhythmias to a greater extent than did halothane. However, the effect of other intravenous anesthetics on epinephrine-induced arrhythmias has not been well discussed. Our study was designed to clarify the effect of propofol and etomidate on epinephrine-induced arrhythmias in dogs. The result is that, we clarified that propofol enhanced epinephrine-induced arrhythmias whereas etomidate did not have significant effect on epinephrine-induced arrhythmias. In addition, we determined that the action of propofol was dose-dependent in the presence of a background of etomidate. (Anesthesiology, 1991)2. Thiopental has been reported to sensitize the heart to the arrhythmogenic action of epinephrine, but the adrenoceptor mechanism involved in the arrhythmogenicity of thiopental remains unknown. We investigated comparative roles of alphal and beta adrenoceptors in myocardial sensitization by thiopental in dogs, and demonstrated that both alphal and beta adrenoceptor activities are important for myocardial sensitization by thiopental to the arrhythmogenic action of epinephrine.3. In order to extent our previous work on adrenoceptor mechanism of epinephrine-induced arrhythmias, we designed an experimental model to clarify the role of betal and beta2 adrenoceptor using halothane-anesthetized dogs. (Can J Anaesth, 1992) In our next work, we intend to elucidate the role of subtypes of beta adrenoceptor in the genesis of arrhythmias during thiopental anesthesia using this experimental model.