The effect of cementum protein-impregnated HAP on the formation of new attachment

本研究旨在评估骨水泥成分在牙种植体周围诱导牙周韧带样组织形成的潜力。将羟基磷灰石（HA）复合或不复合牛骨水泥颗粒植入实验制造的无牙猴颌脊。3个月后处死动物，取出植入物，用切割-格栅系统制备。未钙化切片的组织学检查显示，涂有明胶包埋骨水泥颗粒的羟基磷灰石种植体周围形成了与牙周韧带一致的组织，而未涂有骨水泥颗粒的HA种植体则没有观察到这种牙周组织。结果显示组织与真正的牙周韧带一致，周围的HA种植体涂有牙骨质。这项技术可能被证明是治疗上有用的辅助更自然和功能人工牙替代。

This study was carried out to evaluate the potential of cemental components to induce formation of periodontal ligament-like tissue around dental implants. Hydroxyapatite (HA) implants compounded with and without bovine cemental particles were placed in experimentally created edentulous ridges of monkey jaws. After 3 months animals were sacrificed, and implants were retrieved and studied following preparation with the cutting-griding system. Histologic examination of undecalcified sections revealed that tissue consistent with periodontal ligament was formed surrounding hydroxyapatite implants when coated with gelatine-embedded cemental particles, whereas no such periodontal tissue was observed on the HA implants without cemental particles. Results demonstrate that tissue consistent with a true periodontal ligament from around HA implants coated with cementum. This technique may prove therapeutically useful as an adjunct to more natural and functional artificial tooth replacement.