Molecular mechanisms of WDR24-induced autophagy: Role in AML proliferation and survival (E07*)

GATOR 2蛋白WDR 24对于急性髓性白血病（AML）的增殖和存活至关重要，并且参与选择性自噬的调节。通过结合生物化学，蛋白质组学和基于CRISPR/Cas9的正向遗传方法，该项目旨在阐明WDR 24如何调节选择性自噬，体外表征AML细胞中的潜在信号网络，并分析WDR 24在自噬调节中的作用如何影响AML病理生理学。

The GATOR2-protein WDR24 is essential for proliferation and survival in acute myeloid leukemia (AML), and it is involved in the regulation of selective autophagy. By combining biochemical, proteomic, and CRISPR/Cas9-based forward genetic approaches, this project aims to elucidate how WDR24 regulates selective autophagy, to characterize the underlying signaling network in AML cells in vitro, and to analyze how the role of WDR24 in autophagy regulation impinges on AML pathophysiology.