Preoperative assessment for malignant behavior of upper gastrointestinal tract

桥粒是细胞间的连接点，在上皮细胞粘附中起重要作用。电镜观察发现食管癌细胞桥粒数目减少。桥粒芯糖蛋白I（DGI）是桥粒膜核心的主要成分，在上皮细胞粘附中起重要作用。正常鳞状上皮细胞在其细胞-细胞边界强烈表达DGI。根据DGI表达的强度和模式，将癌组织分为三组：DGI（++）、DGI（+）和DGI（-）。DGI（+）或DGI（-）肿瘤的淋巴结转移率高于DGI（++）。DGI表达与肿瘤浸润、淋巴结转移、淋巴管浸润和血管浸润呈负相关。转移性淋巴结中的DGI表达与原发性肿瘤中的DGI表达相同或强度较低。因此，DGI表达的减少或丧失可促进淋巴结转移。索隆博莫杜尔 ...更多信息 In（TM）是最初在内皮上鉴定的Thorombin受体，并起天然抗凝血剂的作用。TM主要表达于鳞状上皮细胞间的细胞桥。癌组织TM主要表达于细胞间界和胞浆。当TM表达之间的原发性和转移性病变进行比较，TM表达是远远低于在转移性病变比原发性肿瘤。TM表达的下调可能在胃癌的转移过程中起重要作用，胃癌组织中DGI表达的下调与淋巴结转移、淋巴管浸润和淋巴结转移数目有关。DGI的表达与淋巴结转移密切相关，与C-erbB 2、p53、FH 6、PCNA的表达相关，且HLA-DR阳性细胞或S-100蛋白阳性细胞较多的患者生存率明显高于其他患者，这些结果为上消化道恶性肿瘤的发生提供了重要的信息。少

Desmosomes are intercellular junctions which play an important role in epithelial cell adhesion. We reported a decrease in number of desmosomes in esophageal cancer cells as shown by electron microscopic study. Desmoglein I (DGI) is a major component of the desmosomal membrane core that plays an important role in epitherial cell adhesion. Normal squamous epitherial cells strongly expressed DGI at their cell-cell boundaries. According to the intensity and pattern of DGI expression, the cancerous tissues were divided into three groups : DGI (++), DGI (+), and DGI (-). DGI (+) or DGI (-) tumors had lymph node metastases more frequently than DGI (++). A good inverse correlation between DGI expression and tumor invasion, lymph node metastasis, lymphatic invasion and vessel invasion was observed. DGI expression in metastatic lymph nodes was the same or of less intensity, than in the primary tumor. Therefore, reduction or loss of DGI expression may promote lymph node metastases. Thorombomodul … More in (TM) is thorombin receptor that identified originally on the endothelium and acts a natural anticoagulant. TM was immunohistochemically expressed in the squamous epithelium mainly at the intercellular bridges. The carcinoma tissues expressed TM mainly at the cell-cell boundaries and in the cytoplasm. When TM expression was compared between the primary and metastatic lesions, TM expression was far fewer in the metastatic lesions than in the primary tumors. The reduction of TM expression seems to play an important role in the metastatic process.In the patinets with gastric carcinoma, a down-regulation of DGI expression and lymph node metastasis, lymphatic invasion and the number of lymph node metastasis. A close relationship between DGI expression and lymph node metastasis was found, compared with C-erbB2, p53, FH6 and PCNA.Furthermore, survival rate of patients with HLA-DR positive cells or with many S-100 protein positive dendritic cells was significantly better than that of the other patients.These results may provide us with some important infomations for malignant behavior of the upper gastrointestinal tract. Less