SOD activity and localization of SOD in colorectal cancer

从抗氧化系统的角度探讨大肠癌组织中超氧化物歧化酶（SOD）的意义。测定肿瘤组织、癌旁组织及正常组织中SOD活性和硫代巴比妥酸反应物，并结合组织病理学因素进行分析。同时检测癌组织DNA倍体和细胞增殖情况。第二，用Cu，Zn-SOD化学染色法检测癌组织中SOD的活性，并探讨其定位与生物恶性程度的关系，发现癌组织中SOD活性高于其它两个部位。癌组织中SOD活性随分期的进展而升高。影响SOD活性的最显著因素是病毒入侵。SOD的定位并不总是与SOD活性有关，也不能反映肿瘤的生物学恶性程度，阐明肿瘤组织中的抗氧化系统可以为肿瘤的治疗提供更好的策略。测定癌组织和非癌组织中SOD的含量，不仅可以预测化疗和放疗的敏感性，而且可以预测正常细胞的损伤。

The significance of superoxide dismutase (SOD) in colorectal cancer tissue was determined from the aspect of the antioxidant system. SOD activity and thiobarbitueic acid reactive substance were measured in tumor, in tissue ajacent to the tumor, and in normal regions, and the results were analyzed in terms of histo-pathological factors. DNA ploidy pattern and cell proliferation in cancer tissue were also measured. The secondly, immunohisto-chemical stain of Cu, Zn-SOD was examined in cancer tissue, and the relationship between localization of SOD and biological malignancy was also investigated.SOD activity in cancer tissue was higher than in the other two regions. SOD activity in cancer tissue increased with the progression of stage. Vanous invasion was the most significant factor influenceing SOD activity. The localization of SOD is not always connected with SOD activity, and it does not reflect the biological malignancy.The elucidation of the antioxidant system in cancer tissue can provide us with a better strategy for cancer treatment. The estimation of SOD in cancer in cancer and non cancer region is useful for a predictor of not only sensitivty but also normal cell injury by chemotherapy and radiation therapy.