DEVELOPMENT OF AN OXYGENATOR WITH BUILT-IN HEMOCONCENTRATOR

为了简化体外血液循环，方便体外循环的操作，我们将中空纤维气体交换单元和血液过滤单元合二为一，研制了一种具有血液浓缩器功能的新型膜式氧合器。该圆柱形装置由用于血液过滤的中空纤维和外部提供的用于气体交换的另一纤维组成。两者均采用体外血流系统，血液沿径向从中心芯周围流向其周围的中空纤维，首先是血液浓缩器，然后是氧合器。采用这种流动方式，实现了血流在整个纤维中的均匀分布，提高了装置的性能。氧传递速率为336 ml/min，流速为6 L/min，超滤速率为7 L/h，流速为4 L/min，红细胞压积为25%。整个装置的压降仅为60 mmHg，流速为6 L/min。两个机组的组合结构没有造成任何不良影响。综上所述，通过氧合器和血液浓缩器的结合，采用外血流方式，可以获得优异的简化的血液浓缩。

In order to simplify the extracorporeal blood circuit and to facilitate handling of cardiopulmonary bypass, we have combined a hollow fiber unit for gas exchange and that for hemofiltration in one component and developed a new membrane oxygenator with a function of hemoconcentrator. The cylindrical device is consisted of a hollow fiber for hemofiltration with another fiber for gas exchange provided outside. Both of them adopt the blood outside perfusion system, Blood flows from around the center core towards the hollow fiber around it, first hemoconcentrator and then oxygenator, in radial direction. By applying this flow mode, even distribution of blood flow to the entire fiber was realized and the performance of the device was improved. Oxygen transfer rate was 336 ml/min at a flow rate of 6 L/min, and ultrafiltration rate was 7 L/hour with a flow rate of 4 L/min with a hematocrit of 25%. Pressure drop of the whole unit was only 60 mmHg with a flow rate of 6 L/min. The combined structure of the two units has not caused any adverse effects. In conclusion, by combining an oxygenator and a hemoconcentrator, excellent and simplified hemoconcentration is made available as the blood outside flow mode is adopted.