Physiopsychological Studies on Animal Model of Hyperactive (Learning Disability) Children.

研究了新生儿脑多巴胺缺失大鼠的行为和生化特征，该大鼠可能是多动（学习障碍）儿童的动物模型。F344/Du菌株在出生后第2天和第4天给予双侧脑室注射6-羟多巴胺（70mug）。结果如下：1。多动症在发育阶段（早产儿）尤为突出。2. 在某些类型（单向和穿梭）回避任务中出现了明显的学习缺陷，这可能是应激情境下突出的饲养和跳跃反应所致。3. 胃口迷宫学习也变差了。4. 多巴胺能兴奋剂的奖励效应没有改变。5. 脑组织中多巴胺含量显著降低，但胞外多巴胺浓度仍保持较高水平。这些结果表明，新生儿多巴胺耗竭大鼠是一种有希望的多动症儿童动物模型。

Behavioral and biochemical characteristics were investigated in neonatal brain dopamine depleted rats, a possible animal model of hyperactive (learning disability) children. On days 2 and 4 after birth, each rat of F344/Du strain received bilateral intraventricular injections of 6-hydroxydopamine (70mug). The results are as follows.1. Hyperactivity occurs prominently during the developing (premature) age. 2. Marked learning deficits appears on some (one-way and shuttle) types of avoidance tasks, which might be brought from prominent rearing and jumping responses under stressful situation. 3. Appetitive maze learning is also deteriorated. 4. Rewarding effects to dopaminergic stimulants are not changed. 5. Tissue contents of brain dopamine profoundly decrease, but extracellular concentration of dopamine remains to be relatively high. These results suggest that neonatal dopamine depleted rats are a promising animal model of hyperactive children.