The comparative study of MR functional imaging and H_2^<15>O-PET

本课题的研究目的是通过与已建立的H_2^<15>O-PET脑功能检查相比较，探讨fMRI是否能同时评价刺激的初级和关联皮质区，并阐明该激活皮质区的意义。1994年和1995年初进行了基础研究。基础研究表明，利用计算机图形学视频的视觉刺激适合激活大面积皮层，EPI方法适合作为功能磁共振成像的脉冲序列对激活的皮层区域进行三维评价。比较研究是在1995年进行的。受试者为9名成人，在fMRI和H_2^<15>O-PET时均有相同的视觉刺激。两项研究均在两周内完成。两项研究的图像对比如下：fMRI不仅激活了初级视觉皮层，还激活了视觉关联皮层。2、fMRI显示的视觉皮层激活范围与H_2^<15>O-PET几乎相同。3、对单克隆视频和彩色视频激活的视觉关联区进行比较发现，彩色视频激活的视觉关联区通常比单克隆视频大。1,2显示fMRI可以检测到与H_2^<15>O-PET几乎相同的激活视觉皮质区。图3所示的激活视觉皮层的差异可能代表了这种差异对应于参与颜色感知的第四个视觉区域。

The purpose of this research project is whether MR functional imaging (fMRI) can evaluate both primary nad association cortical areas of the stimulation, and can clarify the significance of this activated cortical area by comparing with established brain functional examination of H_2^<15>O-PET.Basic study was carrid out in 1994 and the early period of 1995. Basic study showed that the visual stimulation using the video of computer graphics was suitale for activating the large area of cortex, and EPI method was suitable as the pulse sequence of fMRI for evaluating the activated cortical area three dimensionally.The comparative study was carried out in 1995. Subject was 9 adults, each of them had the same visual stimulation during fMRI and H_2^<15>O-PET.Both studies were done within 2 weeks.The comparison of images of both studies revealed below ;1, fMRI activated not only the primary visual cortex but also visual association cortex.2, The extend of activated isual cortices by fMRI was almost the same as that of H_2^<15>O-PET.3, The comparison between the activated visual association areas by monoclonal video and by color video showed that the latter was usually larger than the former.1,2 revealed that fMRI can detect the activated visual cortical areas as almost the same extend as H_2^<15>O-PET.The difference in the activated visual cortex seen on 3 may repressent that this difference corresponds to the fourth visual area which engages in the color perception.