Experimental Electron Densities, Crystal Engineering and Molecular Recognition: A Supramolecular Approach to Drug Design

GABA受体是治疗从记忆障碍到肌肉痉挛和慢性疼痛等一系列疾病的重要治疗靶点。该项目旨在解决与药物/靶标相互作用相关的一些基本问题。这项工作将使人们更好地理解如何调整药物的化学结构以生产更有效的化合物。该计划的结果将突出澳大利亚作为一个在分子设计方面做出巨大贡献的国家。可以肯定的是，该项目的结果将使澳大利亚受益，因为它将使澳大利亚更好地了解分子的基本性质，以及如何合理地设计其他分子以适应特定的角色。

GABA receptors are important therapeutic targets for the treatment of a number of disorders from memory dysfunction, to muscle spasticity and chronic pain. This project is designed to address some of the fundamental questions associated with drug/target interactions. This work will lead to a greater understanding of how the chemical structure of a drug can be tailored to produce a more effective compound. The outcomes of this program will highlight Australia as a strong contributing nation in molecular design. It is certain that the outcomes of this program will benefit Australia by providing a much greater level of understanding of the fundamental properties of molecules and how others may be rationally designed to suit a specific role.