Studies on the constituents of Thai medicinal plants

在1984.1年度植物学调查的基础上，对泰国部分药用植物的化学成分进行了研究，主要集中在吲哚生物碱。钩藤中的新型二次生物碱从茜草科植物中分离得到四种新生物碱。其中3个化合物具有由传统氧化吲哚生物碱结构修饰而成的新型20，21-二氧代-20，21-二氧代-20，21-秒骨架。另一个为3-氧代-7-羟基-3，7-第二型生物碱。小金花中的生物碱；分离得到5个新生物碱。Kopsijasminilam是一种具有新的20-羟基-21-氧代-20，21-二环阿司匹丁骨架的生物碱。Deoxkopsijasminilam和^&lt；14-kopsijasminilam是同一生物碱结构类别的额外成员。钩吻生物碱的化学成分研究从马钱科植物中分离得到8个新生物碱，并对其结构进行了鉴定。对以前提出的库米定的结构进行了修正。并对这类生物碱的生物模式化合成进行了研究。苦味植物斑茅的化学成分在菊科植物中发现了一种新的甾醇糖苷。化学和波谱研究表明，该化合物具有一个四环的甾醇骨架，具有&lt；@17，9(11)&lt；@d1-杂环共轭二烯和一个新的高氧侧链结构单元。

Chemical studies of the constituents of some Thai medicinal plants, mainly focused on indole alkaloids, were carried out based on our botanical survey in 1984.1. New type seco alkaloids of Uncaria salaccensis; From this Rubiaceae plant four new alkaloids were obtained. Three of them possessed the novel 20,21-dioxo-20,21-secoframework modified from the conventional oxindole alkaloid structure. The remaining one was a 3-oxo-7-hydroxy-3,7-seco-type alkaloid.2. Alkaloids of Kopsia jasminiflora; Five new alkaloids were isolated. Kopsijasminilam was an alkaloid having the novel 20-hydroxy-21-oxo-20,21-seco-aspidofractinine skeleton. Deoxykopsijasminilam and ^<14>-kopsijasminilam were additional members of the same structural class of alkaloids.3. Chemical studies on the alkaloids of Gelsemium elegans; Eight new alkaloids were found in the titled Loganiaceae plant and their structures were determined. The structure of koumidine which was previously presented was revised. Studies on biogenetically patterned synthesis of this gruop of alkaloids were also carried out.4. Constituents of a bitter plant, Vernonia extensa; A new type sterol glucoside was found in the titled compositae plant. Chemical and spectroscopical studies clarified that this compound had a tetracyclic sterol framework possessing <@17,9(11)<@D1-heteroannular conjugated diene and a novel highly-oxygenated side chain structural moiety.