Interaction between anesthetics and various drugs in the canine blood-perfused papillary muscle and sinoatrial node preparations.

在犬离体血液灌注心脏制备物中，可以观察到甚至给予供体犬的药物的直接作用，而在供体动物中，可以观察到通过神经体液代偿反射机制修饰的药物的全身作用。尼卡地平对安氟醚麻醉犬的张力、心率和血压的抑制作用强于清醒犬。两种药物均引起剂量依赖性正性肌力和变时作用。1989年，我们在这个模型中研究了地尔硫卓与七氟醚之间的相互作用。两种药物均延长PQ间期，降低发展性张力。观察到这些作用通过每种其他药物增强。

In the canine isolated, blood-perfused heart preparations the direct effects of the agents which were given even into the donor dog could be observed, while in the donor animal the systemic effects of the agents which would be modified by neurohumoral compensatory reflex mechanisms could be observed.In this model, we observed the interaction between nicardipine and enflurane in 1987. Nicardipine depressed more potently developed tension, heart rate and blood pressure in enflurane anesthetized dogs than in conscious dog.In 1988, we compared the effects of pancuronium and vecuronium in this mode. Both drugs caused dose-dependent positive inotropic and chronotropic effects. These effects were suggested to be mediated by release of norepinephrine from the sympathetic nerve endings.In 1989, we investigated the interaction between diltiazem and sevo- flurane in this model. Both drugs prologed PQ interval and depressed developed tension. These effects were observed to be potentiated by each other drug.