Contingent negative variation (CNV) in tinnitus patients.

我们对39例无明显感音神经性听力损失的耳鸣患者进行了随机负变异（CNV）振幅检测。其中男性20人，女性19人，平均年龄46岁。13名健康的医院工作人员（男性11人，女性2人）作为对照。CNV模式包括一个警告性的声刺激（S1:1KHz,85dBHL），然后在2sec后进行一个强制性的光刺激（S2：光闪）；被摄者必须按下按钮来停止s2光。CNV平均为20-25倍。研究了CNV振幅与抑郁、焦虑等心理状态的关系。采用抑郁评分和mas - 1量表测定后期心理状态。2.耳鸣患者的早期和中期CNV振幅均明显高于对照组（p < 0.05）。2 .耳鸣组反应时间明显长于对照组（p < 0.05）。3 .耳鸣患者耳壁部位P300的振幅明显小于耳鸣患者。当抑郁评分介于正常和抑郁状态之间时，只有早期和中期分量的CNV振幅较低。然而，当抑郁得分高时，CNV的所有成分都很小。这些结果提示耳鸣患者对警告刺激（S1）的超敏反应导致精神活动升高。

Thirty-nine patients complained of tinnitus without significant sensorineural hearing loss were examined for contingent negative variation(CNV) amplitude. Twenty were male and nineteen female and their average age was 46 y.o. Thirteen healthy hospital staff,elevev male and two female,were used for control.their average age was 29 y.o.The CNV paradigm consisted of a warning acoustic stimulus(S1:1KHz,85dBHL) followed by an imperative light stimulus(S2:light flash) 2sec later;the subject had to stop S2-light by pushing a button.CNV was averaged by 20-25 times. The relationship between CNV amplitude and psychological status such as depressive or anxiety,was studied.Later psychological status were determined by means of depressive score and MAS.1.The tinnitus patients showed a significantly large CNV amplitude than control group( p 0.05) in its early and middle components.2. Reaction time was significantly larger in tinnitus patients group than control group(p 0.05).3. Amplitude of P300 which was measured at the parietal site(Pz) was significantly smaller in tinnitus patients.4.When depressin score was in between the normal and depressive status,only early and middle components of CNV was low in its amplitude.However,all components of CNV were small,when depression scores were high. These results suggest the hypersensitivity to the warning stimulus(S1) in tinnitus patients, which leads elevated mental activity.