Twin screw extruder

在布伦斯韦格理工大学制药工程中心(PVZ)，来自机械工程和生命科学学院的科学家，特别是来自过程工程、制药以及微和生产技术领域的科学家，在联合研究项目上进行跨学科的合作。该中心的目标是通过捆绑参与学科的专业知识，开发和表征有效的配方策略以及挑战活性药物成分的制造和加工方法。特别关注那些加工性能困难的活性物质，如那些溶解性差或生物分子结构敏感的物质。关于未来的重要问题，人们感兴趣的主要议题还包括持续生产和个体化药物的开发。随着挤出机的申请，它打算在PVZ建立一个用于这些研究目标的中心技术。除其他外，该设备将用于开发基于挤压和造粒的新型剂型，特别是用于有效和个性化的治疗。在此背景下，将深入了解挤压和造粒以及下游操作中的工艺-结构-性能关系。这涉及对工艺和产品监测方法的研究，以便合理地确定可导出的工艺界限和工艺-质量-相关性，以及开发模拟方法以阐明潜在的微工艺。

At the Center of Pharmaceutical Engineering (PVZ) at TU Braunschweig, scientists from the Faculties of Mechanical Engineering and Life Sciences, in particular from the fields of process engineering, pharmacy as well as micro and production technology, work interdisciplinary on joint research projects. The aim of the center is to develop and characterize efficient formulation strategies as well as manufacturing and processing methods for challenging active pharmaceutical ingredients by bundling the expertise from the participating disciplines. Special attention is paid to active substances with difficult processing properties such as those with poor solubility or sensitive biomolecular structure. With regard to important future issues, major topics of interest also include continuous production and the development of individualized medicines. With the extruder applied for, it is intended to establish a central technology at the PVZ for these research objectives. The device is to be used, among others, for the development of novel, extrusion- and granulation-based dosage forms, in particular for efficient and individualized therapy. In this context, a deep understanding of process-structure-property relationships in extrusion and granulation as well as in downstream operations is going to be developed. This involves research on methods for process and product monitoring in order to define rationally derivable process limits and process-quality-correlations as well as the development of simulation methods for the elucidation of underlying microprocesses.