High Throughput Electrochemical Workstation System for Organic Electrocatalysis and In-Operando Reaction Control

近年来，有机电催化经历了一个显着的复兴，从而成为一个变革性的工具，彻底改变了分子合成。为了通过金属电催化实现可持续的直接功能化，获得最先进的电化学高通量仪器是至关重要的。设想的项目特点是：i）电化学肽后期多样化，ii）电化学聚合物升级，iii）计算研究的验证，iv）3d金属络合物的电催化，v）不对称电催化，所有这些都需要有效优化所有反应参数。到目前为止，公布的程序主要限于恒电流电解，而恒电位制度下的电催化是不可行的，由于缺乏所要求的仪器在哥廷根大学。这一关键限制尤其阻碍了高化学选择性和氧化还原敏感性催化剂。电催化高通量仪器能够实现有效的恒电位歧管。在所需氧化还原转化所需的最低水平下调节氧化电位的选择进一步使电化学成为实现独特化学选择性水平的理想手段。与电合成形成鲜明对比的是，电化学和金属催化的合并需要高度敏感的过渡金属物种的处理和表征。因此，在操作中的反应控制是必不可少的高活性中间体的鉴定和表征。

In recent years, organic electrocatalysis has undergone a remarkable renaissance, thus emerging as a transformative tool that revolutionizes molecular syntheses. To enable sustainable direct functionalizations by metallaelectro-catalysis it is of utmost importance to have access to a state of the art electrochemical high-throughput instrumentaion. The envisioned project features i) electrochemical peptide late-stage diversification, ii) electrochemical polymer upgrading, iii) validation of computational studies, iv) electrocatalysis with 3d metal complexes, and v) asymmetric electrocatalysis, all of which require effective optimization of all reaction parameters. Thus far, published procedures are predominantly restricted to galvanostatic electrolysis, while electrocatalysis under a potentiostatic regime is not viable due to a lack of the requested instrument at the Göttingen University. This key limitation prevents among others high chemo-selectivity and redox-sensitive catalysts. The Electrocatalysis High-Throughput Instrument enables effective potentiostatic manifolds. The option to dial in oxidizing potential at the minimum level required for the desired redox transformation further renders electrochemistry an ideal means to achieve unique levels of chemoselectivity. The merger of electrochemistry and metal catalysis, in stark contrast to electrosynthesis, requires the handling and characterization of highly sensitive transient transition metal species. Thus, in-operando reaction control is essential for the identification and characterization of highly reactive intermediates.