Effects of algal polysaccharide in curing and preventing of cardiovascular disease

在26种海藻中，有13种具有降血压作用，降低总胆固醇(TC)、游离胆固醇(FC)、甘油三酯(TG)和低密度脂蛋白胆固醇(LDL)水平。此外，海藻粉日粮还可使大鼠血清高密度脂蛋白胆固醇水平提高46.0%。对从几种活性海藻中提取的6种海藻多糖进行了研究，发现呋喃多糖对高血压和高胆固醇血症有明显的抑制作用。它的平均分子量为90,500。对喂食生理盐水和含胆固醇饮食的大鼠进行了降血压和降胆固醇的效果检验。扶诺然可显著降低收缩压。同时，福那然组大鼠尿钠、水排出量及钠钾比均较对照组明显增加。此外，福然饮食还能降低血清Na~+/K~+比值。因此，尿液中钠的排泄能力增强可能是降血压的一个重要因素。扶正丸可降低模型大鼠血清TC、Fc、TG、LDL水平及动脉粥样硬化指数。富诺兰饮食增加了粪便中的胆固醇水平。这一发现表明，呋喃丹的降血脂作用可能是由于促进了胆固醇向面部的排泄所致。

Thirteen species among 26 species of seaweeds, some of which are commonly used as food, showed antihypertensive effect and decreased the levels of total cholesterol (TC), free cholesterol (FC), triglyceride (TG), and low density lipoprotein cholesterol (LDL). In addition , the serum level of high density lipoprotein cholesterol (HDL) was elevated 46.0% by the seaweed powder diets. Six polysaccharides derived from several active seaweed species were examined, and funoran was found to have appreciable suppression of hypertention and hypercholesterolemia.The funaran isolated from Gloipeltis tenax consisted mainly of galactose, 3,6-anhydro-galactose sulfate polysaccharide. It had an average molecular weight of 90,500. The effects of funoran to lower blood pressure and cholesterol was examined the rats fed a saline solution and cholesterol-containing diet. Funoran caused significant reduction of systolic blood pressure. At the same time, the increase of sodium, water excretion and sodium potassium ratio in urine in the funaran group was more significant in the experimental rats than in the control group. Moreover, the ratio of Na^+ and K^+ in serum was decreased by the funoran diet. Thus, the enhanced ability of funoran to excrete sodium in urine may be an important factor for decreasing the blood pressure. The funoran decreased the serum TC,FC,TG,and LDL levels, and atherogenic index in the rats. The cholesterol level in feces was increased by the funoran diet. Thses finding indicate that the antihyperlipidemic effect of funoran may be caused the enhanced excretion of cholesterol into faces.