The functional localization of short-term memory in the limibic system.

它试图澄清在“短期记忆”方面，在边缘系统的功能差异，使用几个记忆任务。1)嗅球切除术（OB病变）显著损害了三面板跑道任务中的参考记忆和工作记忆，并延迟了三水平操作任务中的样本匹配（DMTS）表现。二水平操作任务的逆向学习也因OB损伤而明显受损。2)海马背侧（DH）损伤对工作记忆和DMTS表现有明显影响，但对参考记忆无明显影响。此外，反向学习也受到DH损伤的损害。胆碱酯酶抑制剂physostaiming和tetrahydroamino吖啶（THA）改善了DH病变引起的记忆损伤。毒蕈碱类拮抗剂东莨菪碱、烟碱类拮抗剂甲胺、BZP/GABA_A拮抗剂muscimol和chlordiazepoxide、5-HT_<1A>拮抗剂8-OH-DA、NMDA拮抗剂CGS19755和CPP以及L-NAME的NO合成酶抑制剂在海马背侧微注射可引起工作记忆损伤，但不引起参考记忆损伤。3)乳状体损伤对工作记忆和参考记忆均有影响，但对DMTS成绩和逆向学习无影响。而丘脑背内侧（DMT）损伤对DMTS的表现有损害，但不影响3-panel跑道任务和反转学习。THA不能改善mb损伤大鼠和dmt损伤大鼠的记忆损伤。4)基底外侧杏仁核损伤对工作记忆有损害，但对参考记忆无损害。皮质侧杏仁核损伤并未损害工作记忆和参考记忆。东莨菪碱和CPP微注射基底外侧杏仁核对工作记忆有损害，但对参考记忆无损害。5)基底前脑损伤显著损害工作记忆、参考记忆和DMTS表现。逆转学习也受到基底前脑损伤的损害。因此，上述局灶性脑损伤会导致特征性的记忆功能障碍，这取决于大脑受损的部位。这些结果可能为理解记忆的功能定位提供有用的线索。少

It was attempted to clarify the functional difference in the limbic system in regard to "short-term memory", using several memory tasks.1)Olfactry bulbctomy(OB lesion)markedly impaired both reference and working memory in a 3-panel runway tasks and delayd matching-to-sample(DMTS)performance in a 3-lever operant tasks. Reversal learning in a 2-lever operant task was also markedly impaired by OB lesion.2)Dorsal hippocampal(DH)lesion markedly impaired working memory and DMTS performance, but not reference memory. Furthermore, reversal learning was impaired by DH lesion. Cholinesterase inhibitor physostigmine and tetrahydroaminoacridine(THA)improved the impairments of memory produced by DH lesion. While, impaired of working memory, but not reference memory, was produced by microinjection of muscarinic antagonist scopolamine, nicotinic antagonist mecamylamine, BZP/GABA_A agonist muscimol and chlordiazepoxide, 5-HT_<1A>agonist 8-OH-DA, NMDA antagonist CGS19755 and CPP, and NO synthase inhibi … More tor L-NAME into the dorsal hippocampus.3)Mamillary body(MB)lesion produced impairments of both working and reference memory, but not DMTS performance and reversal learning. While, dorsomedial thalamus(DMT)lesion impaired DMTS performance without affecting both 3-panel runway task and reversal learning. THA failed to improve the impairment of memory in both MB-lesioned rats and DMT-lesioned rats.4)Basolateral amygdaloid lesion impaired the working memory, but not reference memory. Corticomedial amygdaloid lesions failed to impair both working and reference memory. Microinjection of scopolamine and CPP into the basolateral amygdala produced impairment of working memory, but not reference memory.5)Basal forebrain lesion markedly impaired both working and reference memory and DMTS performance. Reversal learning was also impaired by the basal forebrain lesion.In this way, focal brain lesions mentioned above resiults in characteristic dysfunction of memory, depending on lesioned site of brain. These results may provide a useful clue for understanding functional localization of memory. Less