Consutruction of a Protein Sequence-Structure Database

简要介绍了本研究所开发的蛋白质数据库的序列结构数据库系统。本研究的目的是建立一个蛋白质数据库的数据库检索系统。例如，我们经常需要从蛋白质名称和作者中查找PDB条目。在另一种情况下，我们想知道具有给定部分序列的肽片段的坐标。蛋白质数据库没有配备任何数据检索系统。蛋白质数据库的使用者可以通过编写程序来获取蛋白质数据库中的必要数据。笔者尝试利用已有的程序建立一个序列结构数据库，该数据库由数据库和检索程序两部分组成。后者是美国国家生物医学研究基金会为蛋白质序列数据库PIR（Protein Identification Resource）开发的程序PSQ的修改版本。在我们的序列结构数据库中，我们以类似于蛋白质序列数据的方式检索PDB数据。本研究首先编制了数据库构建程序，将PDB数据转换为PIR格式。我们的数据库是在DEC公司的VAX/VMS计算机上运行的。

I briefly described a sequence-structure database system of the protein Data Bank which was construted in this study. The purpose of this research is to construct a database retrieval system of the Protein Data Bank. For example, we often needs to find PDB entries from their protein names and authors. In another case, we like to know the coordinates of peptide fragments with a given partial sequence. The Protein Data Bank is not equipped with any data retrieval system. The users of the Protein Data Bank should find some program jot get neccessary data from the Protein Data Bank. I have tried to construct a sequence-structure database by utilizing already-existing programs.The sequence-structure database is made up of two parts : the database and its retrieval program. The latter is a modefied version of Program PSQ, which was developed at National Biomedical Research Foundation, USA for the protein sequence database PIR (Protein Identification Resource). In our sequence-structure database, we retrieve PDB data in a similara way as for protein sequence data. The database construction program was created in this study originary, which converts PDB data into the PIR format. Our database works on VAX/VMS computers of DEC Corporation.