Study on prevention of hepatitis C for hepatitis C viral infection

为建立丙型肝炎病毒(丙型肝炎病毒)潜伏期感染者的流行病学调查方案，通过对丙型肝炎病毒流行区的流行病学调查，发现丙型肝炎病毒感染率为32.4%。从1994年9月和1995年9月的调查中，我们得到以下结果：1.男女血清GOT、GPT、ZTT和TTT水平随着抗-HCV滴度的升高而升高，而总胆固醇和甘油三酯水平则下降。2.饮酒者高于不饮酒者。在感染丙型肝炎病毒的不饮酒者中，总胆固醇和高密度脂蛋白和甘油三酯水平正常，但在感染丙型肝炎病毒的饮酒者中，这些指标下降。这些结果表明，即使在潜在的丙型肝炎病毒感染者中，饮酒也会加重肝损伤的发生。3.丙型肝炎病毒感染者与饮酒有关的丙型肝炎病毒转化率较正常人明显升高，提示丙型肝炎病毒感染影响酒精性肝损害。4.这些结果提示饮酒和丙型肝炎病毒感染同时促进了肝炎的发生。这些结果发表在日本流行病学协会第五届和第六届年会(1995年1月，1996年1月)和日本卫生学会第65届和第66届年会(1995年3月，1996年5月)上。

In order to set up a program for people with latent hepatitis C virus (HCV) infection, this investigation was projected through epidemiological survey in the HCV endemic area where the prevalence of HCV infection was found to be 32.4%. From the survey in September 1994 and 1995, we obtained following results ;1.The levels of GOT,GPT,ZTT and TTT were increased with the increase of titer of anti-HCV in both sexes, whereas those of total-choresterol and triglyceride were decreased.2.Higher levels were found more frequently in alcohol drinkers than in nondrinkers. In nondrinkers with HCV infection, total-and HDL-choresterol and triglyceride were normal levels, but in drinkers with HCV infection, these indicators were decreased. These results suggest that alcohol drinking accentuates the development of liver injury even in people with latent HCV infection.3.gammaGTP was more sharply increased in relation to alcohol intake in people with HCV infection than in healthy people, suggesting that HCV infection affects alcohol-induced liver damage.4.These results suggest that alcohol drinking and HCV infection concomitantly facilitate the development of hepatitis.These results were presented at the 5th and the 6th annual meeting of the Japan epidemiological association (January 1995,1996) , and the 65th and the 66th annual meeting of the Japanese society for hygiene(March 1995, May 1996).