^<31>P Chemical Shift Imaging for Quantitative Measurements of Cardiac High-Energy Phosphate

本研究的目的是确定是否定量测量心脏高能磷酸盐的^P化学位移成像（CSI）是有用的评估心肌活力，并澄清哪一个CSI技术是最合适的。<31>一维CSI研究组包括41例冠状动脉左前降支狭窄（&gt; 50%）的患者和11例健康对照者（C）。根据运动时的~（13）T1显像结果，将患者分为可逆性~（13）T1缺损组（RD [+]，n = 29）和固定性~（13）T1缺损组（RD [-]，n = 12）。<201><201><201>采用选择切片的一维CSI技术获得心脏13P磁共振谱，在表面线圈中心放置标准品进行代谢物定量。<31>方差分析显示，三组间静息时磷酸肌酸均值（SD）差异显著（C，12.14 ± 4.25&gt; RD [+]，7.64 ± 3.00&gt; RD [-]，3.94 ± 1.00&gt; RD [-]，P &lt; 0.01）。<plus-minus><plus-minus><plus-minus> ...更多信息 nus&gt; 2.21 mumol/g湿心脏组织，p &lt;0.05）以及RD [-]组中ATP的显著降低（C，7.72 ± 2.97; RD [+]，6.35 ± 3.17&gt; RD [-]，4.35 ± 1.52 mumol/g湿心脏组织，p &lt;0.05）。<plus-minus><plus-minus><plus-minus>当使用在轴向方向上具有切片选择性激发的二维相位编码技术来测量体模中无机磷酸盐的浓度时，它产生了非常准确的结果。然而，当同样的技术应用于人类心脏时，每个体素（2.5x2.5x2.5-cm ^3）通常不会完全被心肌填充。这导致难以估计体素中的心肌重量。当采用二维相位编码技术并在冠状方向上进行切片选择性激发时，不可能在表面线圈的敏感体积内放置标准品。因此，具有矢状切片选择性激发的一维CSI是用于心脏代谢物测量的最合适的CSI技术，并且对于评价心肌存活性是有用的。少

The aims of this study were to determine whether or not quantitative measurements of cardiac high-energy phosphate by ^<31>P chemical shift imaging (CSI) are useful in assessing myocardial viability and to clarify which CSI technique is the most suitable. The one-dimensional CSI study group was composed of 41 patients with stenosis of the left anterior descending coronary artery (>50%) and 11 healthy control subjects (C). The patients were divided into two groups on the basis of exercise ^<201>Tl scintigraphy : a reversible ^<201>Tl defect group (RD [+] , N=29) and a fixed ^<201>Tl defect group (RD [-] , n=12). Cardiac ^<31>P magnetic resonance spectra were obtained by slice-selected one-dimensional CSI.For metabolite quantification a standard was placed at the center of the surface coil. ANOVA revealed significant differences among the three groups with respect to mean (<plus-minus>SD) phosphocreatine at rest (C,12.14<plus-minus>4.25>RD [+] , 7.64<plus-minus>3.00>RD [-] , 3.94<plus-mi … More nus>2.21 mumol/g wet heart tissue, p<0.05) as well as a significant decrease in ATP in the RD [-] group (C,7.72<plus-minus>2.97 ; RD [+] , 6.35<plus-minus>3.17>RD [-] , 4.35<plus-minus>1.52 mumol/g wet heart tissue, p<0.05). When a two-dimensional phase encoding technique with slice-selective excitation in the axial direction was used to measure the concentration of inorganic phosphate in the phantom, it yielded very accurate results. When the same technique, however, was applied to human heart, each voxel (2.5x2.5x2.5-cm^3) was often not totally filled with myocardium. This led to difficulties in estimating the myocardial weight in the voxel. It was impossible to place a standard within the sensitive volume of the surface coil when employing a two-dimensional phase encoding technique with slice-selective excitation in the coronal direction. Thus, one-dimensional CSI with sagittal slice-selective excitation is the most suitable CSI technique for cardiac metabolite measurements and is useful for the evaluation of myocardial viability. Less