Judgment of chemotherapeutic effecrs on the viability of malignant bone tumors with T1-201SPECT

采用荷人尤文肉瘤的裸鼠模型。T1-201静脉注射后，连续测量血液和肿瘤中的计数，T1-201迅速被肿瘤摄取并逐渐减少。而瘤内放射性在注射后10min迅速升高，此后仍高于血液。尽管顺铂(II)注射后12天肿瘤体积不受影响，但接受顺铂(II)有效化疗的患者与未接受治疗的对照组相比，T1-201的肿瘤摄取显着减少。肿瘤对T1-201的摄取是反映肿瘤细胞活性的敏感指标。对11例恶性骨和软组织肿瘤患者在化疗前和化疗后3-5个疗程(顺铂、盐酸阿霉素、咖啡因)分别注射T1-201 111MBq进行临床研究。在化疗效果显著的病灶中，肿瘤与正常组织的T1-201摄取比似乎小于疗效不明显的病灶，T1-201显像似乎反映了恶性骨或软组织肿瘤的化疗效果。我们将在所有病例的化疗效果评估确定后报告最终结果。

The nude mouse model bearing human Ewing's sarcoma was used. T1-201 was injected intravenously and the counts in the blood and the tumor were measured sequentially.T1-201 was rapidly taken up by the tumor and gradually decreased. While the radioactivity in the tumor was increased rapidly up to 10 min after injection and remained higher than that of blood afterward. Tumor uptake of T1-201 was significantly reduced in patients with effective chemotherapy with cis-diamminedichloroplatinum (II) as compared to the control group without treatment although the tumor volume was not affected by 12 days after cis-diamminedichloroplatinum (II) injection. The tumor uptake of T1-201 was proved to be a sensitive indicator for tumor cell activity.Clinical study was performed by injection of T1-201 111MBq in 11 patients with malignant bone or soft tissue tumors before and after 3-5 courses of chemotherapy (cis-diamminedichloroplatinum (II), doxorubicin hydrochloride, caffeine. T1-201 uptake ratio of the tumor to normal tissue in the lesions with remarkable chemotherapeutic effect seems to be smaller compared to the lesions with inappreciable effect.T1-201 scintigrapy seems to reflect chemotherapeutic effect for malignant bone or soft tissue tumors. We will report the final results after the evaluation of chemotherapeutic effect was derermined in all of cases.