The effect of TNF- alpha on the fibroblast of proliferative scar

肿瘤坏死因子(TNF-α)或Cachectin已被认为是许多宿主对损伤和感染的不良反应的媒介。在烧伤急性期，烧伤患者血清中的肿瘤坏死因子水平升高。此外，这些隆起的水平有助于延迟此类患者的伤口愈合。在这项研究中，我们评估了烧伤患者和瘢痕疙瘩和增生性瘢痕患者的血清肿瘤坏死因子-α水平，以确定这种介质的水平在这些患者中是否持续升高，导致创面愈合受阻。我们的结果表明，严重烧伤患者的血清肿瘤坏死因子-α水平在创伤后5年内显著升高。这可能是这些患者感染率增加和伤口愈合延迟的一个促成因素。目前，我们正在前瞻性地观察肿瘤坏死因子水平和瘢痕形成，因为肿瘤坏死因子和瘢痕形成之间似乎存在阴阳关系。研究表明，低浓度的肿瘤坏死因子有助于伤口愈合，而高浓度的肿瘤坏死因子可能有害。

Tumor Necrosis Factor (TNF-alpha) or Cachectin has been implcated as a mediator of many of the adverse host responses to injury and infection. TNF has been shown to be elevated in the serum of burn patients during the acute phase of burn injury. Also, the level of these elevations contributes to delayd wound healing in such patients. In this study we evaluated the serum TNF-alpha levels of burn patients and the patients of keloid and hypertrophic scar to ascertain whether elevated levels of this mediator persists in these patients, leading to compromised wound healing.Our results indicate that TNF-alpha is significantly elevated in patients with major burns, up to 5 years after the injury. This may pose a contributing factor towards the increased rate of infections and delayd wound healing seen in these patients. We are presently, prospectively looking at TNF levels and scar formation, as there seems to be a yin-yang relationship between TNF and scarring. Studies suggest that TNF in low concentrations helps wound healing, whereas higher concentrations may be detrimental.