The investigation of side dffects to the fingertips caused by dental adhesive monomers.

为了获得牙本质与复合材料之间的完全边缘适合性，牙本质底漆被用作粘结剂。然而，即使牙医试图通过戴橡胶手套来保护他或她的手指免受甲基丙烯酸酯的伤害，指尖也经常会出现红肿、水泡和瘙痒。本研究的目的是检查这些引发剂是否会引起接触性皮炎，并用最大化试验确定20-HEMA、GM和甲基丙烯酸(MA)对豚鼠的致敏和激发的最佳浓度。我们还在封闭斑贴试验中观察了人臂上接触性皮炎的发展情况。致敏浓度为0.2%的HEMA引起强烈的红变和几个水泡泡的形成。致敏浓度为0.5%的GM在24小时内产生强烈的红变。

To obtain complete marginal adaptation between the dentin and the composite, dentin primers are used as adhesives. However, even if the dentist tries to protect his or her fingers from the methacrylates by wearing rubber gloves, rubefaction, tumefaction, blebs and pruritus often occur on the fingertips. The purpose of this study was to examine whether these primers cause contact dermatitis and, using a maximization test, to determine the optimum concentrations of 20-HEMA, GM and methacrylic acid (MA) for sensitization and challenge in guinea pigs. We also observed the development of contact dermatitis on human brachia in a closed-patch test. A sensitizing concentration of 0.2% HEMA resulted in the development of strong rubefaction and several vesiculopapules in response to the challenge. A sensitizing concentration of 0.5% GM produced strong rubefaction at 24 hours.