Interventional Treatment and Molecular Imaging of Coronary and Myocardial Inflammation by Magnetic Resonance Imaging (C15+ (P15))

本项目旨在开发非心肌细胞特异性分子成像造影剂的非侵入性炎症磁共振成像(MRI)，冠状动脉壁的血管内高分辨率MRI，以及介入性实时MRI引导的支架或药物洗脱支架封堵炎症斑块的冠状动脉介入治疗。此外，P15将表征心肌梗死后下游心肌炎症及其异质细胞相互作用，这是由基于导管的冠状动脉闭塞引起的。这些工具将被用来探索体内损伤动力学的时间进展和对干预的反应。

This project aims to develop non-invasive magnetic resonance imaging (MRI) of inflammation with non-myocyte specific molecular imaging contrast agents, intravascular high-resolution MRI of coronary vessel walls, and interventional real-time MRI-guided coronary intervention with implantation of scaffolds or drug eluting stents for sealing of inflamed pla¬ques in a pig model. Furthermore, P15 will characterise downstream myocardial inflammation and its heterocellular interactions after MI, caus¬ed by catheter-based coronary artery occlusion. These tools will be used to explore temporal progression of in vivo lesion dynamics and of res¬ponses to intervention.